Compare Elavil vs. Doxepin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Elavil (amitriptyline)

Prescription only

Zonalon (Doxepin)

Prescription only
Improves mood.

Elavil (amitriptyline) regulates mood and treats nerve pain, but has more side effects than alternatives.

3.3/ 5 average rating with 134 reviewsforElavil
Helps you stop itching.

Zonalon (Doxepin) works well treating itchy skin, but could make you sleepy.

Upsides
  • Elavil (amitriptyline) works well to treat nerve pain and is non-habit forming.
  • In clinical trials, Zonalon (Doxepin) was found to be the most effective cream for treating itchy skin.
  • You can use Zonalon (Doxepin) for up to 8 days at a time.
Downsides
  • Elavil (amitriptyline) has more bothersome side effects than other antidepressants.
  • You need a prescription for Zonalon (Doxepin).
  • It isn't available as a generic, so it could be kind of pricey.
  • Zonalon (Doxepin) can make you sleepy.
  • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
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Used for
  • Skin intching (moderate)
Dosage forms
  • Pill
  • Cream, gel, or ointment
Price
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Reviews
134 reviews so far
53%
saidit'sworth it
36%
saiditworked well
25%
saidit'sa big hassle

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Side effects
The Elavil (amitriptyline) FDA package insert doesn’t have numbers about how common side effects are.
The Zonalon (Doxepin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Mania
    • History of bipolar disorder
    • At risk for bipolar disorder
  • Heart problems
    • History of cardiovascular disease
  • Dizziness and falls
    • Age 65 years or older
    • Taking medicines to control blood pressure
  • Dehydration
    • Age 65 years or older
See more detailed risks and warnings