Compare Eldepryl vs. Symmetrel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Eldepryl (selegiline)

Prescription only

Symmetrel (amantadine)

Prescription only
Treats Parkinson's disease.

Used with other medicines for Parkinson's disease to boost its effect.

Treats Parkinson's disease, the flu, and side effects from antipsychotic drugs.

Symmetrel (amantadine) is a generic medicine that can be used alone, or with other medicines to treat early Parkinson's disease.

Upsides
  • There are two different versions of Eldepryl (selegiline), a quick dissolving tablet and a regular tablet.
  • Eldepryl (selegiline) is one of the recommended medicines you can take along with carbidopa/levodopa if your Parkinson's disease is getting worse.
  • Symmetrel (amantadine) can be taken by itself or with other medicines to treat the symptoms of early Parkinson's disease, including muscle spasms, tremors, and difficulty with movements.
  • Symmetrel (amantadine) is available in generic and in both a pill and liquid form.
  • Compared to other medicines for Parkinson's disease, the side effects are relatively mild.
Downsides
  • You may have to limit the amount of cheese, smoked meat, and soy sauce you eat while taking Eldepryl (selegiline) since it can raise your blood pressure.
  • Can keep you up at night if you take it later in the day
  • Doesn't work by itself to treat Parkinson's disease.
  • Symmetrel (amantadine) sometimes has to be taken multiple times a day.
  • Symmetrel (amantadine) can’t stop or cure Parkinson's disease. It can only slow down the progression.
  • You can't take certain forms of the flu vaccine if you're taking Symmetrel (amantadine). Talk to your doctor before receiving vaccines.
  • You can't stop taking Symmetrel (amantadine) suddenly without talking to your doctor since your Parkinson's can get worse.
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Used for
Dosage forms
  • Pill
  • Dissolving tablet
  • Pill
  • Liquid
Price
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Reviews
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Side effects
11possible side effects
  • Skin irritation at the patch
    24%
  • Headache
    18%
  • Insomnia
    12%
  • Diarrhea
    9%
  • Dry mouth
    8%
  • Weight loss of at least 5%
    5%
  • Indigestion
    4%
  • Rash
    4%
  • Sore throat
    3%
  • Sinus infection
    3%
  • Weight gain of at least 5%
    2%
See more detailed side effects
The Symmetrel (amantadine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Increased blood pressure
    • Eating foods rich in tyramine, like soy sauce, fermented cheese and smoked meats
    • Taking cough and cold medicines like dextromethorphan (Robitussin DM), pseudoephedrine (Sudafed)
  • Serotonin syndrome
    • Tricyclic antidepressants
    • Fentanyl
    • Tramadol
    • Buspirone
    • ADHD medicines
    • Triptans
  • Increased risk of skin cancer
  • Falling asleep during the day
    • Taking other medicines for Parkinson's
  • Low blood pressure
See more detailed risks and warnings
  • Deaths from overdosage
    • Kidney damage or failure
  • Higher risk of suicide
    • Taking Symmetrel (amantadine) for the flu
  • Higher risk of seizures
    • History of seizures
  • Heart failure
    • Heart failure
    • History of swelling in the arms or legs
  • Lack of impulse control
    • Taking other medicines for Parkinson's disease
See more detailed risks and warnings