Compare Eliquis vs. Heparin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Eliquis (apixaban)

Prescription only

Heparin

Prescription only
Prevents blood clots.

Eliquis (apixaban) is an effective way to prevent blood clots from forming in your veins, but you have to take it twice a day, and your doctor might have to change the dose a lot.

3.8/ 5 average rating with 19 reviewsforEliquis
Prevents blood clots.

Heparin is a good anticoagulant that prevents blood clots. However, you'll need to get frequent blood tests to make sure it's working well.

Upsides
  • Eliquis (apixaban) is very effective in reducing the risk of stroke in people with atrial fibrilation or other clotting disorders.
  • You don't need to have regular blood tests on Eliquis (apixaban), and you don't have to regulate your diet like other blood thinners.
  • If you've had clots in your legs or lungs before, Eliquis (apixaban) can lower the risk of these forming again.
  • Safe to use in pregnancy and if you're breast feeding.
  • There are other medications that can help stop unexpected bleeding while taking Heparin.
  • Available as a generic medication.
  • Usually used in the hospital, but can be given at home too.
Downsides
  • You can bruise easier and if you cut yourself, it'll take longer to stop the bleeding. Always look for signs of internal bleeding, such as dark urine or bloody stools.
  • Can't be used if you have artificial heart valves.
  • Never stop taking Eliquis (apixaban) without talking to your doctor first.
  • Eliquis (apixaban) isn't available as a generic, so it can be expensive.
  • If you've taken too much Eliquis (apixaban) and you're bleeding, it can be harder to treat compared to other blood thinners.
  • You'll need to get labs/blood draws done on a regular basis to make sure the drug is working and to make sure you don't get unexpected side effects.
  • You can be at higher risk for bleeding or clotting while taking Heparin compared to other anticoagulants.
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Used for
Dosage forms
  • Pill
  • Injection
Price
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Reviews
19 reviews so far
47%
saidit'sworth it
58%
saiditworked well
21%
saidit'sa big hassle

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Side effects
1possible side effects
  • Major bleed
    2%
See more detailed side effects
The Heparin FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Increased risk of stroke or blood clots from early discontinuation
    • Stopping Eliquis (apixaban) prematurely
  • Paralysis in the spine
    • Spinal puncture (spinal tap)
    • Getting anesthesia in the spine (epidural anesthesia)
    • History of spinal surgery
    • Concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs), or other blood-thinners
  • Interactions with other drugs
  • Increased risk of stroke or bleeding
    • Artificial heart valve
  • Increased side effects in kidney or liver conditions
    • Current kidney problems
    • Current liver problems
See more detailed risks and warnings
  • Unusual bleeding
    • History of bleeding problems
    • Severe high blood pressure
    • Older age
  • Clotting problems
    • Heparin-induced thrombocytopenia
See more detailed risks and warnings