Compare Emend vs. Reglan

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Emend (aprepitant)

Prescription only

Reglan (metoclopramide)

Prescription only
Stops nausea and vomitting caused by chemotherapy and surgery.

Emend (aprepitant) is used with other medicines to stop nausea and vomiting that can happen after chemotherapy and surgery.

Relieves nausea and vomiting.

Reglan (metoclopramide) can stimulate your gut and relieve nausea, but it can only be used for a short period of time due to avoid serious side-effects.

  • Emend (aprepitant) can help stop nausea that lasts several days after receiving chemo, which is harder to control than the nausea that starts immediately.
  • Emend (aprepitant) can also be used to stop nausea in adults that happens after surgery.
  • Emend (aprepitant) also comes as a liquid for children over 6 months and adults who can't take pills.
  • The side effects of Emend (aprepitant) are usually mild and include hiccups and fatigue.
  • Especially useful for relieving nausea caused by cancer chemotherapy.
  • Available in an affordable, generic version
  • If tablets are hard for you to swallow, Reglan (metoclopramide) is also available in as an orally disintegrating tablet or liquid form.
  • Emend (aprepitant) only stops nausea and vomiting from happening. It won't work if you already have nausea and vomiting.
  • Emend (aprepitant) has to be used in combination with other medicines to treat chemotherapy related nausea.
  • Emend (aprepitant) needs to be taken for the first three days of chemo.
  • Use for more than 12 weeks can cause involuntary movements of the eyes, tongue, face, arm, or legs.
  • May take a while to relieve nausea and vomiting caused by delayed gastric emptying.
  • Not a good option if you have Parkinson's disease, history of seizures, or blockage in your gut.
  • You may need a lower dose if you have kidney problems.
Used for
  • Prevention of acute and delayed nausea and vomiting associated with highly-emetogenic chemotherapy
  • Prevention of acute and delayed nausea and vomiting associated with moderately-emetogenic chemotherapy
  • Prevention of postoperative nausea and vomiting
  • Diabetic gastroparesis
  • Gastroesophegeal reflux
  • Prevention of nausea and vomiting associated with chemotherapy
  • Prevention of postoperative nausea and vomiting
  • Radiological exam
  • Small bowel intubation
  • Gastric bezoars
  • Hiccups
  • Acute migraine
  • Treatment of nausea and vomiting in advanced cancer
  • Prevention of radiation therapy-induced nausea and vomiting
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Dissolving tablet
  • Liquid
  • Injectable
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Not enough review data.Leave a review
Not enough review data.Leave a review
Side effects
6possible side effects
  • Fatigue
  • Diarrhea
  • Weakness
  • Indigestion
  • Hiccups
  • Lower white blood cells
See more detailed side effects
4possible side effects
  • Restlessness
  • Drowsiness
  • Fatigue
  • Lack of energy
See more detailed side effects
Risks and risk factors
  • Drug Interactions
  • Decreased INR when used with warfarin (Coumadin)
    • Taking warfarin with Emend (aprepitant)
  • Risk of reduced efficacy of hormone based birth control
    • Taking hormone-based birth control
See more detailed risks and warnings
  • Late, irreversible, involuntary movements (tardive dyskinesia)
    • Elderly
    • Women
    • Diabetics
  • Depression
    • Depression
  • Neuroleptic malignant syndrome
  • Early, reversible involuntary movements (extrapyramidal side-effects)
    • Younger than 30 years old
    • High doses of Reglan (metoclopramide)
    • Children and teens
See more detailed risks and warnings