Compare Emtriva vs. Odefsey

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Works with other medicines to treat HIV infection.

Emtriva (emtricitabine) is a first-line and commonly used drug that is taken in combination with other HIV medications to treat or prevent HIV.

Treats HIV infection

Odefsey (emtricitabine / rilpivirine / tenofovir) is a convenient 3-in-1 medication used to treat HIV infections. It's similar to Complera, but contains a newer HIV drug which has shown to cause less harmful effects on your kidneys and bones.

Upsides
  • Emtriva (emtricitabine) is a first-line drug option used in combination with other HIV medications to treat HIV.
  • Taken with or without food once a day.
  • Emtriva (emtricitabine) is available in many combination tablets if you are looking to lower the number of pills you need to take daily for HIV treatment.
  • Emtriva (emtricitabine) is available as a capsule as well as liquid form.
  • Odefsey (emtricitabine / rilpivirine / tenofovir) combines three medications into one tablet, so it's easy to take.
  • Odefsey (emtricitabine / rilpivirine / tenofovir) is currently the smallest combination HIV tablet available.
  • Odefsey (emtricitabine / rilpivirine / tenofovir) works similar to Complera, but is less likely to cause harmful side effects on your kidneys and bones.
  • Odefsey (emtricitabine / rilpivirine / tenofovir) might be an option for HIV treatment if other HIV drug combinations haven't worked for you.
Downsides
  • Patients with kidney damage will need to be closely monitored by their doctors in order to provide an appropriate dose.
  • Cannot be used by itself to treat or prevent HIV infection.
  • Odefsey (emtricitabine / rilpivirine / tenofovir) has to be taken with a light meal.
  • Cannot be taken with proton pump inhibitors (PPI) like Prilosec or Prevacid. If you need an acid reducer, try taking an antacid like calcium carbonate either 2 hours before or 4 hours after Odefsey (emtricitabine / rilpivirine / tenofovir). Drugs like Pepcid or Zantac (H2RAs) may also be an option, but these should be taken 12 hours before or 4 hours after Odefsey (emtricitabine / rilpivirine / tenofovir).
  • Not recommended for patients who have a significantly high level of viral cells or have a very low level of immune cells.
  • Can cause abnormal heart rhythm.
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Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
Price
Lowest price
$537.62
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Lowest price
$2915.42
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Reviews
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Side effects
18possible side effects
  • Diarrhea
    23%
  • Nausea
    18%
  • Nasal stuffiness/runniness (Rhinitis)
    18%
  • Rash
    17%
  • Physical weakness and/or lack of energy
    16%
  • Increased cough
    14%
  • Headache
    13%
  • Vomiting
    9%
  • Abdominal pain
    8%
  • Insomnia
    7%
  • Depressive disorders
    6%
  • "Pins and needles" feeling (paresthesia)
    5%
  • Dyspepsia
    4%
  • Muscle pain
    4%
  • Dizziness
    4%
  • Nerve weakness/numbness/pain
    4%
  • Joint pain
    3%
  • Abnormal dreams
    2%
See more detailed side effects
8possible side effects
  • Headache
    19%
  • Depression
    19%
  • Somnolence
    14%
  • Nausea
    11%
  • Dizziness
    8%
  • Abdominal pain
    8%
  • Vomiting
    6%
  • Rash
    6%
See more detailed side effects
Risks and risk factors
  • Lactic acidosis | Enlarged, fatty liver
    • Liver disease
    • Women
    • Obesity
  • Worsening hepatitis B infection
    • Hepatitis B Virus infection
  • Immune reconstitution syndrome
    • HIV
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV therapy
  • Similar medications
    • HIV treatment
  • Kidney Damage
    • History of kidney damage
See more detailed risks and warnings
  • Lactic acidosis | Enlarged, fatty liver
    • Liver disease
    • Women
    • Obesity
  • Worsening hepatitis B infection
    • Hepatitis B Virus infection
  • Mood and behavior changes
    • History of mental health problems
  • Bone loss/osteoporosis
    • History of bone fractures
    • Osteoporosis
  • Kidney damage
    • History of kidney damage
    • Taking other medicines that can harm the kidneys
  • Allergic reactions
    • Prior severe allergic reaction to Odefsey (emtricitabine / rilpivirine / tenofovir) or any of its individual drug components.
See more detailed risks and warnings
Learn more about Emtriva (emtricitabine)
Learn more about Odefsey (emtricitabine / rilpivirine / tenofovir)