Compare Enalapril vs. chlorthalidone

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Vasotec (Enalapril)

Prescription only
Lowers blood pressure.

Enalapril is a good blood pressure-lowering medicine that protects kidney function.

3.2/ 5 average rating with 95 reviewsforEnalapril
Lowers blood pressure. Removes extra water from your body.

Thalitone (chlorthalidone) is a well-tolerated water pill that's increasingly used to treat high blood pressure.

  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • The only ACE inhibitor that doctors can give through an IV if that's needed.
  • Does a good job getting rid of extra fluids in your body by making you urinate more.
  • A good blood pressure treatment for people who haven't responded well to other thiazide diuretics. Works especially well for people of African descent.
  • Lowers the risk of heart attack and stroke.
  • Good option if you have high blood pressure and heart failure.
  • Can be good for patients with osteoporosis since it raises the body's level of calcium.
  • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Compared to other ACE inhibitors, less flexible on when you take it. Enalapril needs to be taken multiple times a day on an empty stomach.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
  • Makes you urinate more often.
  • Doesn't work well in people with severe kidney problems.
  • Since Thalitone (chlorthalidone) works longer in the body than other thiazide diuretics, it has a higher chance of causing electrolyte changes.
  • Thalitone (chlorthalidone) can lead to more gouty attacks in people with gout.
  • Don't use this if you have a sulfa allergy.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
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95 reviews so far
saidit'sworth it
saiditworked well
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Side effects
14possible side effects
  • Dizziness
  • Hypotension
  • Orthostatic Effects
  • Syncope
  • Chest Pain
  • Fatigue
  • Abdominal Pain
  • Asthenia
  • Orthostatic Hypotension
  • Angina Pectoris
  • Diarrhea
  • Headache
  • Vertigo
  • Cough
See more detailed side effects
The Thalitone (chlorthalidone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Harm to fetus
    • Women of childbearing age
  • Cough
  • Unusual tongue swelling
    • African descent
  • Heart problems due to high potassium
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
See more detailed risks and warnings
  • Electrolyte disturbances
  • Higher risk for gout attacks
    • History of gout
  • Increased blood sugars
    • History of diabetes
  • Reduced kidney performance
    • History of kidney disease
    • History of acute kidney failure
    • History of azotemia
  • Caution in liver disease
    • History of liver problems
  • Low blood pressure
    • Taking with alcohol
    • Taking other medicines that make you less alert
See more detailed risks and warnings