Compare Enalapril vs. spironolactone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Vasotec (Enalapril)

Prescription only
Lowers blood pressure.

Enalapril is a good blood pressure-lowering medicine that protects kidney function.

3.2/ 5 average rating with 95 reviewsforEnalapril
Removes extra water from your body.

Aldactone (spironolactone) should be used with other medicines to get rid of excess fluid in your body, especially if you have heart failure.

Upsides
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • The only ACE inhibitor that doctors can give through an IV if that's needed.
  • Has a low risk of causing muscle problems from low potassium levels in your blood.
  • More useful when taken with another diuretic that'll also help your body get rid of extra fluids.
  • Can lower blood pressure.
  • Reduces the risk of death in people with heart failure.
Downsides
  • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Compared to other ACE inhibitors, less flexible on when you take it. Enalapril needs to be taken multiple times a day on an empty stomach.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
  • Aldactone (spironolactone) doesn't work well on its own. It should be used with another drug to help get rid of excess fluids.
  • Has many possible side effects, especially when higher doses are used.
  • Can increase the risk of tumor growth.
  • You'll need to have blood tests done regularly since Aldactone (spironolactone) can affect your potassium levels and kidneys.
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Dosage forms
  • Pill
  • Liquid
  • Pill
Price
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Reviews
95 reviews so far
44%
saidit'sworth it
40%
saiditworked well
21%
saidit'sa big hassle

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Side effects
14possible side effects
  • Dizziness
    8%
  • Hypotension
    7%
  • Orthostatic Effects
    2%
  • Syncope
    2%
  • Chest Pain
    2%
  • Fatigue
    2%
  • Abdominal Pain
    2%
  • Asthenia
    2%
  • Orthostatic Hypotension
    2%
  • Angina Pectoris
    2%
  • Diarrhea
    2%
  • Headache
    2%
  • Vertigo
    2%
  • Cough
    2%
See more detailed side effects
The Aldactone (spironolactone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Harm to fetus
    • Women of childbearing age
  • Cough
  • Unusual tongue swelling
    • African descent
  • Heart problems due to high potassium
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
See more detailed risks and warnings
  • Tumor development
  • Low blood pressure
    • Taking with alcohol
    • Taking other medicines that lower your blood pressure
  • Heart problems from high potassium
    • Current kidney problems
    • Taking other medicines that increase potassium
    • Use of salt substitutes
  • Breast pain or swelling
See more detailed risks and warnings