Compare Enbrel vs. Simponi

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Enbrel (etanercept)

Prescription only

Simponi (golimumab)

Prescription only
Calms down your immune system to prevent joint damage.

Enbrel (etanercept) effectively calms down your immune system, but it puts you at risk of serious infections.

3.7/ 5 average rating with 90 reviewsforEnbrel
Calms down the immune system.

Simponi (golimumab) effectively calms down your immune system, but it is given as a shot and puts you at risk of serious infections like tuberculosis or hepatitis B.

Upsides
  • People taking Enbrel (etanercept) for rheumatoid arthritis showed significant improvement and were able to reduce the dose or stop their other RA medicines.
  • Enbrel (etanercept) can work for you even if other medications didn't help your rheumatoid arthritis.
  • Enbrel (etanercept) is the first biologic approved for moderate to severe rheumatoid arthritis. Since it has been around for a long time, its side effects are well known.
  • Many people have only minor or no side effects.
  • It's available as a pre-filled syringe and SureClick auto-injector pen which some people find more convenient and easier to use.
  • Simponi (golimumab) is only injected once a month.
  • Simponi (golimumab) comes in a prefilled syringe or autoinjector. You won't need to measure out the medication.
  • While taking Simponi (golimumab), you may continue to use other drugs prescribed by your doctor that help treat your condition, such as NSAIDS (like ibuprofen) and steroids.
Downsides
  • Enbrel (etanercept) raises your risk of serious or life-threatening infections, including tuberculosis (TB).
  • Enbrel (etanercept) can increase the risk of lymphoma, leukemia and other cancers.
  • May not be the best choice if you have a history of heart failure or nervous system problems like multiple sclerosis.
  • You'll need to have regular blood tests before and during treatment to make sure you don't have any problems taking Enbrel (etanercept).
  • You could get injection site reactions such as redness, swelling, rash, itching, or bruising.
  • Like other immunosuppressive drugs, Simponi (golimumab) can awaken (reactivate) infections.
  • Simponi (golimumab) can increase the risk of lymphoma, leukemia, and other cancers.
  • Not the best choice if you have a history of heart failure or nervous system problems like multiple sclerosis.
  • You'll need to have regular blood tests before and during treatment to make sure you don't have any problems taking Simponi (golimumab).
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Used for
Dosage forms
  • Injection
  • Injection
Price
Lowest price
$4846.44
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Lowest price
$1729.98
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Reviews
90 reviews so far
62%
saidit'sworth it
53%
saiditworked well
17%
saidit'sa big hassle

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Side effects
5possible side effects
  • Any infection
    27%
  • Upper respiratory infections
    17%
  • Injection site reactions
    15%
  • Non-upper respiratory infections
    12%
  • Diarrhea
    3%
See more detailed side effects
11possible side effects
  • Common cold
    16%
  • Injection site reaction
    6%
  • Viral infections (such as influenza and herpes)
    5%
  • Increased liver function test (ALT)
    4%
  • Increased liver function test (AST)
    3%
  • High blood pressure
    3%
  • Bronchitis
    2%
  • Superficial fungal infections
    2%
  • Sinusitis
    2%
  • Dizziness
    2%
  • Tingling sensation
    2%
See more detailed side effects
Risks and risk factors
  • Serious allergic reactions
    • Latex allergy
  • Heart problems
    • History of heart failure
  • Serious infections
    • Taking other immunosuppressant drugs
    • Age 65 or older
  • Cancer
    • Taking other immunosuppressant drugs
    • History of cancer
  • Nervous system effects
    • History of nervous system conditions
  • Lower blood cell counts
See more detailed risks and warnings
  • High risk of infections with TNF inhibitors
    • Taking other immunosuppressant drugs
    • Age 65 or older
    • Active, chronic, or recurrent infection
  • Cancer
    • Taking other immunosuppressant drugs
    • History of malignancy
    • People with rheumatoid arthritis
    • Adolescent age
  • Nervous system effects
    • History of neurologic condition
  • History of heart failure
    • History of heart failure
  • Lower number of blood cells
See more detailed risks and warnings