Compare Endometrin vs. Aygestin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Supports other fertility treatments.

Endometrin (progesterone vaginal insert) is a vaginal insert used in fertility treatments, but you have to apply it more often than progesterone vaginal gel.

3.0/ 5 average rating with 55 reviewsforEndometrin
Regulates your menstrual cycle and treats irregular bleeding.

Aygestin (norethindrone) regulates the menstrual cycle and treats heavy or irregular vaginal bleeding. It's easy to take and isn't expensive.

2.7/ 5 average rating with 30 reviewsforAygestin
  • Helps increase your chances of getting pregnant.
  • Exposes your body to less hormone compared to progesterone pills or injections.
  • Endometrin (progesterone vaginal insert) replaces low levels of progesterone to prepare the lining of your uterus to receive and nourish a fertilized egg.
  • Endometrin (progesterone vaginal insert) comes with step-by-step instructions and is easy to use. Unlike some progesterone products that must be inserted lying down, Endometrin (progesterone vaginal insert) can be inserted while you are standing, sitting, or lying on your back with your knees bent.
  • Helps to regulate your period.
  • Decreases bleeding from hormone imbalance.
  • Available as a generic medication, so it costs less.
  • Endometrin (progesterone vaginal insert) can cause vaginal irritation and burning.
  • Inserting the applicator can possibly cause discomfort or infection.
  • Endometrin (progesterone vaginal insert) is dosed 2 to 3 times a day, compared to other progesterone products that are dosed 1 to 2 times a day.
  • You can't use tampons or other vaginal products for at least 6 hours before and 6 hours after using Endometrin (progesterone vaginal insert).
  • Only available as brand name, so it may be expensive.
  • Can make you gain weight.
  • Higher risk of blood clots.
  • Not for people who are post-menopausal, pregnant, or breast-feeding.
  • Can cause a lot of side effects.
Used for
  • Pain caused by endometriosis
  • Balances hormones in women who don't have regular monthly periods
  • Balances hormones in women who have unusual monthly periods
  • In vitro fertilization
Dosage forms
  • Vaginal insert
  • Pill
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55 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

Have you used Endometrin (progesterone vaginal insert)?

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30 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

Have you used Aygestin (norethindrone)?

Leave a review
Side effects
11possible side effects
  • Pain after egg harvesting
  • Stomach pain
  • Nausea
  • Overstimulation of ovaries
  • Stomach bloating and swelling
  • Constipation
  • Fatigue
  • Headache
  • Uterine spasm
  • Vaginal bleeding
  • Vomiting
See more detailed side effects
The Aygestin (norethindrone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Heart disease and blood clots
    • History of heart disease
    • History of blood clots
  • Depression
    • History of depression
  • Use of other vaginal products
See more detailed risks and warnings
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Abnormal vision changes
  • Depression
    • History of depression
  • Changes in blood sugar levels
    • Diabetes
  • Liver problems
    • History of liver problems
  • High cholesterol levels
    • High cholesterol levels
See more detailed risks and warnings