Compare Endometrin vs. Prometrium

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Supports other fertility treatments.

Endometrin (progesterone vaginal insert) is a vaginal insert used in fertility treatments, but you have to apply it more often than progesterone vaginal gel.

3.0/ 5 average rating with 55 reviewsforEndometrin
Taken for irregular bleeding or paired with estrogen replacements for menopause.

Prometrium (Progesterone) regulates menstrual cycles, treats heavy bleeding, and prevents thickening of the uterus.

3.4/ 5 average rating with 64 reviewsforPrometrium
  • Helps increase your chances of getting pregnant.
  • Exposes your body to less hormone compared to progesterone pills or injections.
  • Endometrin (progesterone vaginal insert) replaces low levels of progesterone to prepare the lining of your uterus to receive and nourish a fertilized egg.
  • Endometrin (progesterone vaginal insert) comes with step-by-step instructions and is easy to use. Unlike some progesterone products that must be inserted lying down, Endometrin (progesterone vaginal insert) can be inserted while you are standing, sitting, or lying on your back with your knees bent.
  • Helps to regulate your menstrual cycle.
  • Relives pain from endometriosis.
  • Lowers the risk of uterine cancer when used with estrogen in women with an intact uterus.
  • Available as a capsule or an injection, so you can choose what works best for you.
  • Endometrin (progesterone vaginal insert) can cause vaginal irritation and burning.
  • Inserting the applicator can possibly cause discomfort or infection.
  • Endometrin (progesterone vaginal insert) is dosed 2 to 3 times a day, compared to other progesterone products that are dosed 1 to 2 times a day.
  • You can't use tampons or other vaginal products for at least 6 hours before and 6 hours after using Endometrin (progesterone vaginal insert).
  • Only available as brand name, so it may be expensive.
  • Prometrium (Progesterone) capsules contain peanut oil, so you can't take it if you're allergic to peanuts.
  • Prometrium (Progesterone) can cause serious birth defects in babies, so you can't take Prometrium (Progesterone) if you’re pregnant or breast-feeding.
  • Increases your risk of blood clots.
Used for
Dosage forms
  • Vaginal insert
  • Pill
  • Injection
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55 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

Have you used Endometrin (progesterone vaginal insert)?

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64 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

Have you used Prometrium (Progesterone)?

Leave a review
Side effects
11possible side effects
  • Pain after egg harvesting
  • Stomach pain
  • Nausea
  • Overstimulation of ovaries
  • Stomach bloating and swelling
  • Constipation
  • Fatigue
  • Headache
  • Uterine spasm
  • Vaginal bleeding
  • Vomiting
See more detailed side effects
The Prometrium (Progesterone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Heart disease and blood clots
    • History of heart disease
    • History of blood clots
  • Depression
    • History of depression
  • Use of other vaginal products
See more detailed risks and warnings
  • Breast cancer
    • Personal or family history of breast cancer
  • Ovarian cancer
    • Family history of ovarian cancer
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Hypertension
    • Diabetes
    • High cholesterol
    • Systemic lupus erythematosus (SLE)
  • Severe allergic reactions
    • Allergy to peanuts
  • Fluid retention (Foot and leg swelling)
    • Heart failure
    • Kidney problems
    • Obesity
  • Depression
    • History of depression
See more detailed risks and warnings