Compare entacapone vs. bromocriptine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Comtan (entacapone)

Prescription only

Parlodel (bromocriptine)

Prescription only
Treats Parkinson's disease.

Comtan (entacapone) enhances the effect of carbidopa/levodopa. It's usually added on when carbidopa/levodopa starts to lose its effect on Parkinson's disease.

Used with other medicines to treat Parkinson's disease, and to stabilize certain hormones.

Parlodel (bromocriptine) is a good medicine to add to other medicines for Parkinson's disease when they start to not work so well.

Upsides
  • Allows you to get more out of carbidopa/levodopa, especially in later stages of Parkinson's disease.
  • Comtan (entacapone) is available in a single pill combination with carbidopa/levodopa.
  • Parlodel (bromocriptine) is a good choice to take with other medicines for Parkinson's disease because it raises your dopamine levels differently than others.
  • Parlodel (bromocriptine) is available as generic.
  • Parlodel (bromocriptine) pills can be broken in half for more personalized dosing.
Downsides
  • Must be taken with other medicines for Parkinson's disease
  • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
  • Can make you very sleepy
  • May require frequent adjustments before finding the dose that works best for you
  • Parlodel (bromocriptine) is only recommended for Parkinson's disease to take with other medicines. It's not a first choice medicine.
  • Your doctor might have to change the dose of Parlodel (bromocriptine) often.
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Reviews
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Side effects
21possible side effects
  • Difficulty controlling movements
    25%
  • Nausea
    14%
  • Muscle spasm
    10%
  • Changes in urine color
    10%
  • Diarrhea
    10%
  • Muscle rigidity
    9%
  • Dizziness
    8%
  • Abdominal pain
    8%
  • Fatigue
    6%
  • Constipation
    6%
  • Vomiting
    4%
  • Dry mouth
    3%
  • Shortness of breath
    3%
  • Purple spots on the skin
    3%
  • Increased sweating
    2%
  • Back pain
    2%
  • Anxiety
    2%
  • Sleepiness
    2%
  • Indigestion
    2%
  • Flatulence
    2%
  • Weakness
    2%
See more detailed side effects
9possible side effects
  • Nausea
    18%
  • Constipation
    14%
  • Low blood pressure
    6%
  • Loss of appetite
    4%
  • Dry mouth/stuffy nose
    4%
  • Indigestion
    4%
  • Cold arms/legs
    3%
  • Drowsiness
    3%
  • Vomiting
    2%
See more detailed side effects
Risks and risk factors
  • Falling asleep during the day
    • Taking other medicines for Parkinson's
  • Changes in behavior
  • Low blood pressure and fainting
    • Low blood pressure
    • Taking medicines for high blood pressure
  • Lack of impulse control
    • Taking other medicines for Parkinson's disease
  • Diarrhea
  • Difficulty controlling movements
See more detailed risks and warnings
  • Sleepiness
  • Low blood pressure
  • High blood pressure
    • Having high blood pressure
    • Delivering a baby
  • Blood vessel issues
    • Acromegaly (Higher growth hormone in the body)
    • History of stomach ulcers
  • Lack of impulse control
    • Taking other medicines for Parkinson's disease
See more detailed risks and warnings