Compare entacapone vs. carbidopa / levodopa extended release
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Treats Parkinson's disease.
Comtan (entacapone) enhances the effect of carbidopa/levodopa. It's usually added on when carbidopa/levodopa starts to lose its effect on Parkinson's disease.
Treats Parkinson's disease.
Sinemet CR (carbidopa / levodopa extended release) is the first choice treatment for Parkinson's disease.
Upsides
- Allows you to get more out of carbidopa/levodopa, especially in later stages of Parkinson's disease.
- Comtan (entacapone) is available in a single pill combination with carbidopa/levodopa.
- Sinemet CR (carbidopa / levodopa extended release) is released over a long period of time in your body and can allow you to take fewer pills less frequently.
Downsides
- Must be taken with other medicines for Parkinson's disease
- Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
- Can make you very sleepy
- May require frequent adjustments before finding the dose that works best for you
- Sinemet CR (carbidopa / levodopa extended release) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
- Your saliva, sweat and urine may have dark color and stain your clothing while taking Sinemet CR (carbidopa / levodopa extended release).
- Sinemet CR (carbidopa / levodopa extended release) will lose its effect over time. If you notice it wearing off sooner than you'd like, talk to your doctor.
- Sinemet CR (carbidopa / levodopa extended release) may cause unusual cravings in some people.
Used for
Dosage forms
- Pill
- Extended release
Price
Lowest price
$240.41
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$24.24
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Side effects
21possible side effects
- Difficulty controlling movements25%
- Nausea14%
- Muscle spasm10%
- Changes in urine color10%
- Diarrhea10%
- Muscle rigidity9%
- Dizziness8%
- Abdominal pain8%
- Fatigue6%
- Constipation6%
- Vomiting4%
- Dry mouth3%
- Shortness of breath3%
- Purple spots on the skin3%
- Increased sweating2%
- Back pain2%
- Anxiety2%
- Sleepiness2%
- Indigestion2%
- Flatulence2%
- Weakness2%
15possible side effects
- Difficulty controlling movements17%
- Nausea6%
- Hallucinations4%
- Confusion4%
- Dizziness3%
- Depression2%
- Urinary tract infection2%
- Headache2%
- Unusual dreams2%
- Muscle spasms2%
- Vomiting2%
- Upper respiratory infection2%
- Shortness of breath2%
- Periods of immobility2%
- Back pain2%
Risks and risk factors
- Falling asleep during the day
- Taking other medicines for Parkinson's
- Changes in behavior
- Low blood pressure and fainting
- Low blood pressure
- Taking medicines for high blood pressure
- Lack of impulse control
- Taking other medicines for Parkinson's disease
- Diarrhea
- Difficulty controlling movements
- Falling asleep during the day
- Taking other medicines for Parkinson's
- High fever and confusion
- Stopping Sinemet CR (carbidopa / levodopa extended release) suddenly
- Changes in behavior
- Lack of impulse control
- Taking other medicines for Parkinson's disease
- Changes in blood pressure and falls