Compare entacapone vs. Mirapex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

ADVERTISEMENT

Comtan (entacapone)

Prescription only

Mirapex (pramipexole)

Prescription only
Treats Parkinson's disease.

Comtan (entacapone) enhances the effect of carbidopa/levodopa. It's usually added on when carbidopa/levodopa starts to lose its effect on Parkinson's disease.

Helps with movement problems.

Mirapex (pramipexole) is effective for Parkinson's disease or restless legs syndrome, but can cause extreme drowsiness that affects daily living.

Upsides
  • Allows you to get more out of carbidopa/levodopa, especially in later stages of Parkinson's disease.
  • Comtan (entacapone) is available in a single pill combination with carbidopa/levodopa.
  • Mirapex (pramipexole) may be better for older people with Parkinson's since it causes fewer movement and mental changes than its alternatives.
  • Mirapex (pramipexole) comes in extended-release form to help reduce side effects and ease administration.
  • Available as a generic so it will be cheaper than similar brand medications.
Downsides
  • Must be taken with other medicines for Parkinson's disease
  • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
  • Can make you very sleepy
  • May require frequent adjustments before finding the dose that works best for you
  • Mirapex (pramipexole) can be used by itself, but is usually used in combination with other medications to treat Parkinson's.
  • Not the best choice if you have kidney problems.
  • You cannot suddenly stop taking Mirapex (pramipexole) if you have been taking it for a long time.
ADVERTISEMENT
Used for
Dosage forms
  • Pill
  • Pill
  • Extended release
Price
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Reviews
Not enough review data.Leave a review
Not enough review data.Leave a review
Side effects
21possible side effects
  • Difficulty controlling movements
    25%
  • Nausea
    14%
  • Muscle spasm
    10%
  • Changes in urine color
    10%
  • Diarrhea
    10%
  • Muscle rigidity
    9%
  • Dizziness
    8%
  • Abdominal pain
    8%
  • Fatigue
    6%
  • Constipation
    6%
  • Vomiting
    4%
  • Dry mouth
    3%
  • Shortness of breath
    3%
  • Purple spots on the skin
    3%
  • Increased sweating
    2%
  • Back pain
    2%
  • Anxiety
    2%
  • Sleepiness
    2%
  • Indigestion
    2%
  • Flatulence
    2%
  • Weakness
    2%
See more detailed side effects
36possible side effects
  • Postural hypotension
    53%
  • Muscle rigidity
    47%
  • Extrapyramidal syndrome
    28%
  • Insomnia
    27%
  • Dizziness
    26%
  • Hallucinations
    17%
  • Accidental injury
    17%
  • Dream abnormalities
    11%
  • Confusion
    10%
  • Muscle weakness
    10%
  • Constipation
    10%
  • Sleepiness
    9%
  • Muscle problems
    8%
  • Gait abnormalities
    7%
  • Muscle tenseness
    7%
  • Dry mouth
    7%
  • Memory loss
    6%
  • Urinary frequency
    6%
  • General swelling
    4%
  • Urinary tract infection
    4%
  • Shortness of breath
    4%
  • Accomodation abnormalities
    4%
  • Restlessness
    3%
  • Thinking abnormalities
    3%
  • Chest pain
    3%
  • Malaise
    3%
  • Runny nose
    3%
  • Vision abnormalities
    3%
  • Arthritis
    3%
  • Paranoid reaction
    2%
  • Urinary incontinence
    2%
  • Lung infection
    2%
  • Twitching
    2%
  • Swelling of joints
    2%
  • Peripheral swelling
    2%
  • Skin disorders
    2%
See more detailed side effects
Risks and risk factors
  • Falling asleep during the day
    • Taking other medicines for Parkinson's
  • Changes in behavior
  • Low blood pressure and fainting
    • Low blood pressure
    • Taking medicines for high blood pressure
  • Lack of impulse control
    • Taking other medicines for Parkinson's disease
  • Diarrhea
  • Difficulty controlling movements
See more detailed risks and warnings
  • Impulse control problems
  • Problems with concentration
    • Taking with alcohol
    • Taking other medicines that make you sleepy
    • Sleep disorders
  • Low blood pressure
    • Taking blood pressure medicines
  • Kidney problems
    • Kidney problems
  • Skin cancer
    • Parkinson's disease
  • Hallucinations and behavior changes
    • Age 65 years or older
    • History of psychosis
    • Advanced Parkinson's disease
See more detailed risks and warnings