Compare entacapone vs. Rytary
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Treats Parkinson's disease.
Comtan (entacapone) enhances the effect of carbidopa/levodopa. It's usually added on when carbidopa/levodopa starts to lose its effect on Parkinson's disease.
Treats Parkinson's disease.
Rytary (carbidopa / levodopa) can be used to treat Parkinson's disease, but it can be expensive.
Upsides
- Allows you to get more out of carbidopa/levodopa, especially in later stages of Parkinson's disease.
- Comtan (entacapone) is available in a single pill combination with carbidopa/levodopa.
- Rytary (carbidopa / levodopa) comes in 4 different strengths.
- If you have private prescription insurance, there are programs to make Rytary (carbidopa / levodopa) more affordable.
Downsides
- Must be taken with other medicines for Parkinson's disease
- Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
- Can make you very sleepy
- May require frequent adjustments before finding the dose that works best for you
- There are other forms of Rytary (carbidopa / levodopa) that are generic and much cheaper.
- Your doctor might have to change the dose of Rytary (carbidopa / levodopa) often before they find a dose that works for you.
- Rytary (carbidopa / levodopa) can cause uncontrollable movements to happen, but this doesn't happen for 3 to 5 years.
- Rytary (carbidopa / levodopa) is not a cure for Parkinson's disease; it can only slow the disease down.
Used for
Dosage forms
- Pill
- Extended release capsule
Price
Lowest price
$82.97
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$17.23
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Side effects
21possible side effects
- Difficulty controlling movements25%
- Nausea14%
- Muscle spasm10%
- Changes in urine color10%
- Diarrhea10%
- Muscle rigidity9%
- Dizziness8%
- Abdominal pain8%
- Fatigue6%
- Constipation6%
- Vomiting4%
- Dry mouth3%
- Shortness of breath3%
- Purple spots on the skin3%
- Increased sweating2%
- Back pain2%
- Anxiety2%
- Sleepiness2%
- Indigestion2%
- Flatulence2%
- Weakness2%
11possible side effects
- Nausea20%
- Headache17%
- Dizziness12%
- Dry mouth7%
- Trouble sleeping6%
- Abnormal dreams5%
- Difficulty controlling movements5%
- Anxiety5%
- Vomiting5%
- Changes in blood pressure5%
- Constipation2%
Risks and risk factors
- Falling asleep during the day
- Taking other medicines for Parkinson's
- Changes in behavior
- Low blood pressure and fainting
- Low blood pressure
- Taking medicines for high blood pressure
- Lack of impulse control
- Taking other medicines for Parkinson's disease
- Diarrhea
- Difficulty controlling movements
- Falling asleep during the day
- Taking other medicines for Parkinson's disease
- High fever and confusion
- Stopping Rytary (carbidopa / levodopa) suddenly
- Changes in behavior
- Lack of impulse control
- Taking other medicines for Parkinson's disease
- Heart attack
- History of heart attack
- High risk for heart attack