Compare Epclusa vs. Copegus

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats hepatitis C.

Epclusa (velpatasvir / sofosbuvir) is a combination medicine that treats hepatitis C, and has been shown very effective at curing the disease in many people. It is very expensive.

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  • Epclusa (velpatasvir / sofosbuvir) is the first medicine approved to treat all genotypes of hepatitis C.
  • Most people only have to take one pill of Epclusa (velpatasvir / sofosbuvir) once a day for 12 weeks. If you have severe liver damage, you'll have to take it with ribavirin.
  • It can be taken with or without food.
  • The most common side effects are usually mild, including fatigue and headache.
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  • Epclusa (velpatasvir / sofosbuvir) can only be absorbed properly in an acidic stomach so heartburn meds can affect how well it works.
  • Epclusa (velpatasvir / sofosbuvir) can cause serious drops in heart rate when it is taken with amiodarone.
  • If you have severe liver disease, you'll have to take Epclusa (velpatasvir / sofosbuvir) with another medication called ribavirin.
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Used for
  • Hematopoietic stem cell transplant - Respiratory syncytial virus infection Hepatitis C
  • Chronic
  • Combination therapy in interferon alfa-naive patients with compensated liver disease - HIV infection Hepatitis C
  • Chronic
  • With compensated liver disease Respiratory syncytial virus infection
  • Herpes simplex Influenza Viral hemorrhagic fever
Dosage forms
  • Pill
  • Pill
  • Liquid
  • Inhaler
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Side effects
5possible side effects
  • Headache
  • Fatigue
  • Nausea
  • Weakness
  • Insomnia
See more detailed side effects
The Copegus (Ribavirin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Hepatitis B reactivation
    • History of hepatitis B infection
  • Slower heart beat
    • Amiodarone
    • Beta blockers
    • Heart disease
    • Liver disease
  • Drug interactions
  • Ribavirin warnings
    • Taking ribavirin with Epclusa (velpatasvir / sofosbuvir)
See more detailed risks and warnings
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