Compare Epclusa vs. Olysio

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats hepatitis C.

Epclusa (velpatasvir / sofosbuvir) is a combination medicine that treats hepatitis C, and has been shown very effective at curing the disease in many people. It is very expensive.

Treats hepatitis C infection.

Olysio (simeprevir) is effective in treating chronic hepatitis C, but it must be used with other antiviral medicines.

Upsides
  • Epclusa (velpatasvir / sofosbuvir) is the first medicine approved to treat all genotypes of hepatitis C.
  • Most people only have to take one pill of Epclusa (velpatasvir / sofosbuvir) once a day for 12 weeks. If you have severe liver damage, you'll have to take it with ribavirin.
  • It can be taken with or without food.
  • The most common side effects are usually mild, including fatigue and headache.
  • Most people who take Olysio (simeprevir) together with other antiviral medicines have good results, with no signs of virus found in their blood three months later.
  • Unlike some other hepatitis C medications, you can take Olysio (simeprevir) even if you are taking an acid reflux medication.
  • Can take Olysio (simeprevir) for a shorter amount of time than other hepatitis C medications.
  • Has less side effects than some hepatitis C medications.
Downsides
  • Epclusa (velpatasvir / sofosbuvir) can only be absorbed properly in an acidic stomach so heartburn meds can affect how well it works.
  • Epclusa (velpatasvir / sofosbuvir) can cause serious drops in heart rate when it is taken with amiodarone.
  • If you have severe liver disease, you'll have to take Epclusa (velpatasvir / sofosbuvir) with another medication called ribavirin.
  • There's no generic available, so it can be very expensive.
  • Olysio (simeprevir) should not be used alone, it must be used together with other antiviral medicines.
  • There are many interactions between Olysio (simeprevir) and other drugs and herbal supplements. Talk to your doctor or pharmacist before starting any new medications.
  • Olysio (simeprevir) can cause a rash if you're out in the sun, so you'll have to use sunblock or wear protective clothing.
  • Olysio (simeprevir) only works with one specific type of hepatitis C, unlike others that treat all 6 types.
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Used for
Dosage forms
  • Pill
  • Pill
Price
Lowest price
$24754.11
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Reviews
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Side effects
5possible side effects
  • Headache
    22%
  • Fatigue
    15%
  • Nausea
    9%
  • Weakness
    5%
  • Insomnia
    5%
See more detailed side effects
5possible side effects
  • Rash
    28%
  • Itchy skin
    22%
  • Nausea
    22%
  • Muscle pain
    16%
  • Trouble breathing
    12%
See more detailed side effects
Risks and risk factors
  • Hepatitis B reactivation
    • History of hepatitis B infection
  • Slower heart beat
    • Amiodarone
    • Beta blockers
    • Heart disease
    • Liver disease
  • Drug interactions
  • Ribavirin warnings
    • Taking ribavirin with Epclusa (velpatasvir / sofosbuvir)
See more detailed risks and warnings
  • Hepatitis B reactivation
    • History of hepatitis B infection
  • Slow heart rate
    • Amiodarone
    • Beta blockers
    • Heart disease
    • Liver disease
  • Drug interactions
    • Rifampin
    • St. John's wort
  • Ribavirin combination treatment
    • Taking ribavirin with Olysio (simeprevir)
  • Skin problems
    • Taking Olysio (simeprevir) in combination with rivabirin and peg-interferon alfa
See more detailed risks and warnings