Compare Epclusa vs. Viekira XR
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Treats hepatitis C.
Epclusa (velpatasvir / sofosbuvir) is a combination medicine that treats hepatitis C, and has been shown very effective at curing the disease in many people. It is very expensive.
A combination of 3 different medicines that treats hepatitis C infection.
Viekira XR (ombitasvir, paritaprevir, ritonavir, and dasabuvir) is a once daily drug regimen consisting of 3 pills a day that are effective against genotype 1 hepatitis C virus, but may not be a good option if you have liver problems.
Upsides
- Epclusa (velpatasvir / sofosbuvir) is the first medicine approved to treat all genotypes of hepatitis C.
- Most people only have to take one pill of Epclusa (velpatasvir / sofosbuvir) once a day for 12 weeks. If you have severe liver damage, you'll have to take it with ribavirin.
- It can be taken with or without food.
- The most common side effects are usually mild, including fatigue and headache.
- Unlike Viekira Pak, Viekira XR (ombitasvir, paritaprevir, ritonavir, and dasabuvir) is only three pills that is taken all at once.
- Similar to Viekira Pak, Viekira XR (ombitasvir, paritaprevir, ritonavir, and dasabuvir) has a 95% to 100% cure rate.
- Common side effects are manageable and include feeling nauseous, tired, itching, or rash.
- Viekira XR (ombitasvir, paritaprevir, ritonavir, and dasabuvir) can also be used to treat genotype 1 hepatitis C if you have a liver transplant.
Downsides
- Epclusa (velpatasvir / sofosbuvir) can only be absorbed properly in an acidic stomach so heartburn meds can affect how well it works.
- Epclusa (velpatasvir / sofosbuvir) can cause serious drops in heart rate when it is taken with amiodarone.
- If you have severe liver disease, you'll have to take Epclusa (velpatasvir / sofosbuvir) with another medication called ribavirin.
- Viekira XR (ombitasvir, paritaprevir, ritonavir, and dasabuvir) is a combination of 3 different medications which may be hard to take if you don't like swallowing a lot of pills.
- You may need to take an additional medication called ribavirin with Viekira XR (ombitasvir, paritaprevir, ritonavir, and dasabuvir).
- If you are taking ethinyl estradiol-containing medications, you will need another form of birth control during and for 2 weeks after using Viekira XR (ombitasvir, paritaprevir, ritonavir, and dasabuvir).
- Should not be used if you experienced severe rash after taking ritonavir (Norvir).
- Your doctor will need to take frequent blood tests during the first 4 weeks, and periodically after to monitor your liver function.
Used for
- Hepatitis C infection genotype 1
Dosage forms
- Pill
- Pill
Price
Lowest price
$24754.11
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Reviews
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Side effects
5possible side effects
- Headache22%
- Fatigue15%
- Nausea9%
- Weakness5%
- Insomnia5%
6possible side effects
- Fatigue34%
- Nausea22%
- Itching18%
- Skin reactions16%
- Trouble sleeping14%
- Weakness/Lack of energy14%
Risks and risk factors
- Hepatitis B reactivation
- History of hepatitis B infection
- Slower heart beat
- Amiodarone
- Beta blockers
- Heart disease
- Liver disease
- Drug interactions
- Ribavirin warnings
- Taking ribavirin with Epclusa (velpatasvir / sofosbuvir)
- Hepatitis B reactivation
- Hepatitis B infection
- Serious liver problems and complications
- Moderate to severe liver disease (Child Pugh B or C)
- Raised liver blood tests
- Taking estrogen containing medications
- Ribavirin warnings
- Drug interactions
- HIV resistance
- HIV infection