Compare Epclusa vs. Zepatier

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats hepatitis C.

Epclusa (velpatasvir / sofosbuvir) is a combination medicine that treats hepatitis C, and has been shown very effective at curing the disease in many people. It is very expensive.

Treats hepatitis C.

Zepatier (elbasvir / grazoprevir) is a combination pill that treats hepatitis C genotypes 1 and 4, but it can't be used if you have moderate to severe liver disease.

Upsides
  • Epclusa (velpatasvir / sofosbuvir) is the first medicine approved to treat all genotypes of hepatitis C.
  • Most people only have to take one pill of Epclusa (velpatasvir / sofosbuvir) once a day for 12 weeks. If you have severe liver damage, you'll have to take it with ribavirin.
  • It can be taken with or without food.
  • The most common side effects are usually mild, including fatigue and headache.
  • Zepatier (elbasvir / grazoprevir) can cure hepatitis C, which means the virus can't be detected in the blood 3 months after completing treatment.
  • If you only need to take Zepatier (elbasvir / grazoprevir), it’s just 1 pill once a day for 12 or 16 weeks.
  • Zepatier (elbasvir / grazoprevir) can be taken by people with kidney problems, even those on hemodialysis.
  • Zepatier (elbasvir / grazoprevir) usually has mild side effects.
Downsides
  • Epclusa (velpatasvir / sofosbuvir) can only be absorbed properly in an acidic stomach so heartburn meds can affect how well it works.
  • Epclusa (velpatasvir / sofosbuvir) can cause serious drops in heart rate when it is taken with amiodarone.
  • If you have severe liver disease, you'll have to take Epclusa (velpatasvir / sofosbuvir) with another medication called ribavirin.
  • Zepatier (elbasvir / grazoprevir) doesn't work for all genotypes of hepatitis C. It should only be used for genotype 1 or 4.
  • Some people need to take Zepatier (elbasvir / grazoprevir) together with another medication called ribavirin. Ribavirin has its own set of side effects.
  • You shouldn’t take Zepatier (elbasvir / grazoprevir) if you have moderate to severe liver disease.
  • If you've ever had hepatitis B virus infection, the virus could become active again during or after treatment with Zepatier (elbasvir / grazoprevir). Before starting it, your doctor will do blood tests to check for hepatitis B virus.
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Used for
  • Hepatitis C infection genotype 1 and 4
Dosage forms
  • Pill
  • Pill
Price
Lowest price
$24754.11
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Lowest price
$18081.15
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Reviews
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Side effects
5possible side effects
  • Headache
    22%
  • Fatigue
    15%
  • Nausea
    9%
  • Weakness
    5%
  • Insomnia
    5%
See more detailed side effects
3possible side effects
  • Nausea
    11%
  • Headache
    11%
  • Tiredness
    5%
See more detailed side effects
Risks and risk factors
  • Hepatitis B reactivation
    • History of hepatitis B infection
  • Slower heart beat
    • Amiodarone
    • Beta blockers
    • Heart disease
    • Liver disease
  • Drug interactions
  • Ribavirin warnings
    • Taking ribavirin with Epclusa (velpatasvir / sofosbuvir)
See more detailed risks and warnings
  • Hepatitis B reactivation
    • History of hepatitis B infection
  • Risks and warnings of ribavirin
    • Taking ribavirin with Zepatier (elbasvir / grazoprevir)
  • Abnormally high liver test
    • Female
    • Asian
    • Age 65 or older
  • Drug interactions
See more detailed risks and warnings