Compare Epivir vs. Videx

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Works with other medicines to treat HIV infection or chronic hepatitis B.

Epivir (lamivudine) is a first-choice and commonly used medicine to take together with other HIV medications to treat HIV. It is also an alternative option for treating chronic hepatitis B.

Works with other medicines to treat HIV infection.

Videx (didanosine) is not a first-choice treatment for HIV because there are newer medications that work well and are easier to take. However, Videx (didanosine) can be an option if other HIV medications haven't worked for you.

Upsides
  • Epivir (lamivudine) can be used with many other HIV options to create a combination that's right for you.
  • Has very minimal interactions with other medications.
  • Available in tablet and liquid form.
  • Can be take once or twice a day. Also available in different combination pills so you don't have to take as many pills per day.
  • Available in cheaper generic form.
  • Videx (didanosine) is available in pill or liquid form.
  • Videx (didanosine) can be used in children 2 weeks of age and older.
  • Videx (didanosine) can be taken either once or twice daily.
Downsides
  • Cannot take Epivir (lamivudine) by itself to treat HIV.
  • Might need to change dosage based on how well your kidneys function.
  • It is recommended to use other options to treat chronic hepatitis B before choosing Epivir (lamivudine) due to drug resistance.
  • You'll have to be tested for both HIV and hepatitis B, since the dose to treat hepatitis B is lower than the dose for HIV. If you have the lower dose, HIV can be harder to treat if you also have hepatitis B.
  • The liquid version of Epivir (lamivudine) has sugar, so if you have diabetes, your blood sugar levels might change.
  • Videx (didanosine) cannot be taken by itself. It must be used with other HIV medications to treat HIV.
  • People commonly experience side effects such as diarrhea, nerve pain, and nausea when taking Videx (didanosine).
  • Videx (didanosine) should be used with caution if you have liver or kidney issues.
  • Videx (didanosine) shouldn't be taken with allopurinol or ribavirin. If you are taking these medicines, let your doctor know.
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Used for
  • HIV infection
  • Hepatitis B
  • HIV prevention, non-occupational (PEP)
  • HIV prevention, mother-to-child
Dosage forms
  • Pill
  • Liquid
  • Delayed release Pill
  • Liquid
Price
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Reviews
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Side effects
3possible side effects
  • Ear, nose, and throat infections
    25%
  • Diarrhea
    14%
  • Sore throat
    13%
See more detailed side effects
6possible side effects
  • Diarrhea
    56%
  • Nerve pain
    25%
  • Nausea
    24%
  • Headache
    22%
  • Rash
    14%
  • Vomiting
    14%
See more detailed side effects
Risks and risk factors
  • Lactic acidosis | Enlarged, fatty liver
    • Liver disease
    • Women
    • Obesity
  • Acute Exacerbation of Hepatitis B Virus (HBV)
    • Hepatitis B virus
  • Different doses available
  • HIV counseling/testing
  • Immune reconstitution syndrome
    • HIV
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV therapy
  • Pancreatitis
See more detailed risks and warnings
  • Pancreatitis
    • History of pancreatic issues
    • Alcohol consumption
    • Concomitant use with Zerit (stavudine)
    • Kidney problems
  • Lactic acidosis & severe liver damage
  • Nerve pain
    • Advanced HIV disease
    • History of peripheral neuropathy
    • Taking other medications that also cause peripheral neuropathy
  • Retinal changes
  • Fat redistribution
    • HIV treatment
  • Immune reconstitution syndrome
    • HIV
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV therapy
See more detailed risks and warnings