Compare Erygel vs. Differin
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Akne-Mycin (Erythromycin) is a very common acne treatment you apply to the skin that may work better when combined with other topical medicines.
Differin (adapalene) is commonly used for treating acne, but, it can cause skin irritation.
- Applying erythromycin to the skin reduces the amount of acne bacteria and "calms" the skin down (lowers the inflammatory response) in acne.
- Available in a gel formulation which may be better if your skin is very oily.
- Better choice if you're pregnant. erythromycin is categorized as pregnancy Category B (likely safe) as compared to similar topical medicines that are Category C (weigh risks vs benefits).
- Differin (adapalene) is a good option for the treatment of acne.
- It is available as a cheaper, generic medication.
- It only has to be applied to the skin once a day at bedtime.
- The 0.1% gel formulation is available over the counter, without a prescription.
- Differin (adapalene) is generally well tolerated, with few side effects.
- There's a risk of irritation with anything you apply to your skin and this is no different. erythromycin, like other topical antibiotics, can cause skin irritation and may appear as redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
- It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas
- Studies show it works better when combined with other topical medicines to fight acne and reduce the risk of it losing its effectiveness over time.
- Can cause severe inflammation of the large intestine (pseudomembranous colitis)
- Stop using if you don't notice any improvement in your acne after 6-8 weeks. The most time you can use it is three months.
- Your skin may look worse before it starts looking better.
- Differin (adapalene) can take up to 8 to 12 week to start working.
- Cream, gel, or ointment
- Topical solution
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- Skin dryness42%
- Skin redness38%
- Skin scaling35%
- Persistent burning and stinging24%
- Persistent itching21%
- Allergic reaction
- Skin irritation
- Using other medicines or products that irritate the skin
- Extreme temperatures (hot or cold)
- Development of more serious infections
- Local skin reactions
- Soaps and cleansers with skin-drying effects
- Products with high concentraions of alcohol, astringents, spices, or limes.
- UV and sunlight exposure
- Severe allergic reaction