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Akne-Mycin (Erythromycin)

Prescription only

Differin (adapalene)

Prescription or OTC
Topical treatment for acne.

Akne-Mycin (Erythromycin) is a very common acne treatment you apply to the skin that may work better when combined with other topical medicines.

3.4/ 5 average rating with 93 reviewsforErygel
Treats acne.

Differin (adapalene) is commonly used for treating acne, but, it can cause skin irritation.

Upsides
  • Applying erythromycin to the skin reduces the amount of acne bacteria and "calms" the skin down (lowers the inflammatory response) in acne.
  • Available in a gel formulation which may be better if your skin is very oily.
  • Better choice if you're pregnant. erythromycin is categorized as pregnancy Category B (likely safe) as compared to similar topical medicines that are Category C (weigh risks vs benefits).
  • Differin (adapalene) is a good option for the treatment of acne.
  • It is available as a cheaper, generic medication.
  • It only has to be applied to the skin once a day at bedtime.
  • The 0.1% gel formulation is available over the counter, without a prescription.
  • Differin (adapalene) is generally well tolerated, with few side effects.
Downsides
  • There's a risk of irritation with anything you apply to your skin and this is no different. erythromycin, like other topical antibiotics, can cause skin irritation and may appear as redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
  • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas
  • Studies show it works better when combined with other topical medicines to fight acne and reduce the risk of it losing its effectiveness over time.
  • Can cause severe inflammation of the large intestine (pseudomembranous colitis)
  • Stop using if you don't notice any improvement in your acne after 6-8 weeks. The most time you can use it is three months.
  • Your skin may look worse before it starts looking better.
  • Differin (adapalene) can take up to 8 to 12 week to start working.
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Used for
Dosage forms
  • Cream, gel, or ointment
  • Topical solution
  • Cream
  • Gel
  • Lotion
Price
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Reviews
93 reviews so far
46%
saidit'sworth it
34%
saiditworked well
19%
saidit'sa big hassle

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Side effects
1possible side effects
  • Burning
    25%
See more detailed side effects
5possible side effects
  • Skin dryness
    42%
  • Skin redness
    38%
  • Skin scaling
    35%
  • Persistent burning and stinging
    24%
  • Persistent itching
    21%
See more detailed side effects
Risks and risk factors
  • Allergic reaction
  • Skin irritation
    • Using other medicines or products that irritate the skin
    • Eczema
    • Extreme temperatures (hot or cold)
  • Development of more serious infections
See more detailed risks and warnings
  • Local skin reactions
    • Soaps and cleansers with skin-drying effects
    • Products with high concentraions of alcohol, astringents, spices, or limes.
  • UV and sunlight exposure
  • Severe allergic reaction
See more detailed risks and warnings