Compare Estazolam vs. Doxepin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Prosom (estazolam)

Prescription only

Zonalon (Doxepin)

Prescription only
Helps you stay asleep longer.

Prosom (estazolam) can help you sleep, but you might feel hungover the next day.

Helps you stop itching.

Zonalon (Doxepin) works well treating itchy skin, but could make you sleepy.

Upsides
  • Prosom (estazolam) is available in generic.
  • In clinical trials, Zonalon (Doxepin) was found to be the most effective cream for treating itchy skin.
  • You can use Zonalon (Doxepin) for up to 8 days at a time.
Downsides
  • Prosom (estazolam) isn't recommended if you're age 65 or older because the side effects can be more intense.
  • You can become dependent on Prosom (estazolam) if you take it for more than a few weeks.
  • If you stop Prosom (estazolam) suddenly after taking it for a while, your insomnia might come back even worse than when you started.
  • You need a prescription for Zonalon (Doxepin).
  • It isn't available as a generic, so it could be kind of pricey.
  • Zonalon (Doxepin) can make you sleepy.
  • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
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Used for
  • Skin intching (moderate)
Dosage forms
  • Pill
  • Cream, gel, or ointment
Price
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Reviews
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Side effects
19possible side effects
  • Sleepiness
    42%
  • Headache
    16%
  • Weakness
    11%
  • Difficulty controlling muscles
    8%
  • Nervousness
    8%
  • Dizziness
    7%
  • Uneasiness
    5%
  • Nausea
    4%
  • Abnormal coordination
    4%
  • Leg and foot pain
    3%
  • Hangover
    3%
  • Common cold symptoms
    3%
  • Back pain
    2%
  • Body pain
    2%
  • Indigestion
    2%
  • Confusion
    2%
  • Depression
    2%
  • Abnormal dreams
    2%
  • Abnormal thoughts
    2%
See more detailed side effects
The Zonalon (Doxepin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Tolerance and addiction
    • Using Prosom (estazolam) for more than 10 days
  • Behavior changes
    • Drinking alcohol
    • Taking sedative medicines
  • Hangover effect
    • People age 65 or older
  • Allergic reactions
See more detailed risks and warnings