Compare Estazolam vs. doxepin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Prosom (estazolam)

Prescription only

doxepin

Prescription only
Helps you stay asleep longer.

Prosom (estazolam) can help you sleep, but you might feel hungover the next day.

Treats depression and anxiety.

doxepin can treat depression and anxiety, but it's not a first choice medication because of its many side effects.

Upsides
  • Prosom (estazolam) is available in generic.
  • doxepin has been consistently shown to improve symptoms of depression and anxiety.
  • doxepin has been used to treat depression for over forty years.
Downsides
  • Prosom (estazolam) isn't recommended if you're age 65 or older because the side effects can be more intense.
  • You can become dependent on Prosom (estazolam) if you take it for more than a few weeks.
  • If you stop Prosom (estazolam) suddenly after taking it for a while, your insomnia might come back even worse than when you started.
  • doxepin can make you very sleepy. Try taking it at bedtime if you need to be alert during the day.
  • You shouldn't drink alcohol with doxepin. It can worsen side effects like drowsiness.
  • You have to take it daily, especially if you are feeling better, for the medicine to do its job.
  • It can have more side effects than other antidepressants, like weight gain and increased appetite, decreased libido, and sleepiness.
  • It's not unusual for people to try different antidepressants until they find one that works for them.
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Used for
Dosage forms
  • Pill
  • Pill
  • Liquid
Price
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Reviews
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Side effects
19possible side effects
  • Sleepiness
    42%
  • Headache
    16%
  • Weakness
    11%
  • Difficulty controlling muscles
    8%
  • Nervousness
    8%
  • Dizziness
    7%
  • Uneasiness
    5%
  • Nausea
    4%
  • Abnormal coordination
    4%
  • Leg and foot pain
    3%
  • Hangover
    3%
  • Common cold symptoms
    3%
  • Back pain
    2%
  • Body pain
    2%
  • Indigestion
    2%
  • Confusion
    2%
  • Depression
    2%
  • Abnormal dreams
    2%
  • Abnormal thoughts
    2%
See more detailed side effects
The doxepin FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Tolerance and addiction
    • Using Prosom (estazolam) for more than 10 days
  • Behavior changes
    • Drinking alcohol
    • Taking sedative medicines
  • Hangover effect
    • People age 65 or older
  • Allergic reactions
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 years or under
  • Unmasking of bipolar disorder
    • Bipolar disorder
  • Serotonin syndrome
    • Taking MAOIs (monoamine oxidase inhibitors)
  • Heart problems
    • History of heart disease
    • Adults over 65
    • Electrolyte imbalance
  • Sleepiness
    • Adults 65 years or older
    • Taking other medicines that cause drowsiness (antihistamines, sleep medications, narcotic pain medications)
    • Alcohol
  • Dizziness and falls
    • Age 65 years or older
See more detailed risks and warnings