Compare Estring vs. Divigel
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Relieves vaginal dryness due to menopause.
Estring (estradiol vaginal ring) is more convenient than other forms of estrogen therapy since you only have to replace it every 3 months, but it needs to be inserted directly into the vagina.
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3.3/ 5 average rating with 56 reviewsforEstring
Relieves hot flashes due to menopause.
Divigel (Estradiol gel) is an easy to use medicine that comes in 3 different strengths. It uses lower doses of estrogen than other hormone replacements.
Upsides
- Many women find Estring (estradiol vaginal ring) more comfortable to use and easier to apply than creams or gels.
- Estring (estradiol vaginal ring) may be more convenient since it is dosed once every 3 months compared to alternatives that need to taken daily or twice weekly.
- Works directly at the site of application and safer than oral estrogen pills.
- Replaces estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
- Good for people who don't want to or can't take daily pills.
- Can take the easy to use, pre-measured packets anywhere.
- Divigel (Estradiol gel) has fewer side effects than pills since there are lower amounts of estrogen in gels.
- In studies, many women on the lowest dose started to feel better about a month after starting the medicine. People using the highest doses felt better in just 2 weeks.
Downsides
- Estring (estradiol vaginal ring) may not be the best option if you have a narrow vagina or frequent vaginal infections.
- The ring can fall out without you noticing.
- Estring (estradiol vaginal ring) is only available as brand name, so can be expensive.
- Estring (estradiol vaginal ring) All estrogen therapies increase your risk for uterine cancer, heart problems, and blood clots.
- Increases your risk of endometrial and breast cancer.
- If you have your uterus, you have to use Divigel (Estradiol gel) with another hormone called progestin to lower your risk of uterine cancer.
- Can't be used in people with liver problems.
- It's possible to expose other people to the estrogen before it's absorbed by your skin.
- Can be expensive since it's only available as a brand name product.
Used for
- Vaginal dryness and inflammation
Dosage forms
- Vaginal ring
- Gel
Price
Lowest price
$483.27
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$167.66
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Reviews
56 reviews so far
63%
saidit'sworth it
39%
saiditworked well
18%
saidit'sa big hassle
Have you used Estring (estradiol vaginal ring)?
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Side effects
20possible side effects
- Headache13%
- Vaginal discharge7%
- Back pain6%
- Yeast infection6%
- Upper airway infection5%
- Vaginal inflammation5%
- Vaginal discomfort/pain5%
- Arthritis4%
- Trouble sleeping4%
- Stomach pain4%
- Sinus infection4%
- Vaginal bleeding4%
- Bacterial growth in the genitals4%
- Joint pain3%
- Nausea3%
- Flu-like symptoms3%
- Bone pain2%
- Bladder infection2%
- Hot flashes2%
- Stress2%
5possible side effects
- Breast pain6%
- Unusual vaginal bleeding6%
- Common cold4%
- Lung infection2%
- Yeast infection2%
Risks and risk factors
- Uterine cancer
- Using estrogen for more than one year
- Higher dose of estrogen
- Breast cancer
- Personal or family history of breast cancer
- Using estrogen and progestin for more than one year
- Blood clots and stroke
- Personal or family history of blood clots
- Smoking
- Obesity
- Systemic lupus erythematosus (SLE)
- Heart disease
- Smoking
- Obesity
- High blood pressure
- High blood sugar
- High cholesterol
- Age 50 or older
- Dementia
- Age 65 or older
- Inflammation of pancreas (pancreatitis)
- High levels of triglycerides
- Endometrial cancer
- Using estrogen for more than one year
- Breast cancer
- Personal or family history of breast cancer
- Using estrogen for more than one year
- Increased risk of blood clots and stroke
- Personal or family history of blood clots
- Smoking
- Obesity
- Systemic lupus erythematosus (SLE)
- Increased risk of heart disease
- Smoking
- Obesity
- High blood pressure
- High blood sugar
- High cholesterol
- Age 50 or older
- Dementia
- Age 65 or older
- Pancreas swelling (pancreatitis)
- High levels of triglycerides