Compare Estring vs. Evamist

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Relieves vaginal dryness due to menopause.

Estring (estradiol vaginal ring) is more convenient than other forms of estrogen therapy since you only have to replace it every 3 months, but it needs to be inserted directly into the vagina.

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3.3/ 5 average rating with 56 reviewsforEstring
Relieves hot flashes due to menopause.

Evamist (Estradiol Spray) is easy to use, absorbs well into your skin without needing to rub it in, and is a good option if you don’t want to use estrogen pills or patches.

Upsides
  • Many women find Estring (estradiol vaginal ring) more comfortable to use and easier to apply than creams or gels.
  • Estring (estradiol vaginal ring) may be more convenient since it is dosed once every 3 months compared to alternatives that need to taken daily or twice weekly.
  • Works directly at the site of application and safer than oral estrogen pills.
  • Evamist (Estradiol Spray) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness, low energy).
  • Dries faster than topical estrogen gels.
  • Good for people who don't want to take daily pills.
  • Fewer side effects than pills since lower amounts of estrogen are used in topical sprays.
  • Women in studies have seen the severity and number of hot flashes lower by half within 4 weeks of using Evamist (Estradiol Spray).
  • Very few women had skin irritation from the medicine.
  • Depending on your symptoms, your dose may change, but you can still use the same spray pump no matter what your dose is.
  • Can lower your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
Downsides
  • Estring (estradiol vaginal ring) may not be the best option if you have a narrow vagina or frequent vaginal infections.
  • The ring can fall out without you noticing.
  • Estring (estradiol vaginal ring) is only available as brand name, so can be expensive.
  • Estring (estradiol vaginal ring) All estrogen therapies increase your risk for uterine cancer, heart problems, and blood clots.
  • Increases your risk of endometrial and breast cancer.
  • If you have your uterus, you have to use Evamist (Estradiol Spray) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
  • It's possible to expose other people to the estrogen before it's absorbed by your skin.
  • Can be expensive since it's only available as a brand name product.
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Used for
  • Vaginal dryness and inflammation
  • Hot flashes and night sweats
Dosage forms
  • Vaginal ring
  • Spray
Price
Lowest price
$537.27
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Lowest price
$90.23
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Reviews
56 reviews so far
63%
saidit'sworth it
39%
saiditworked well
18%
saidit'sa big hassle

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Side effects
20possible side effects
  • Headache
    13%
  • Vaginal discharge
    7%
  • Back pain
    6%
  • Yeast infection
    6%
  • Upper airway infection
    5%
  • Vaginal inflammation
    5%
  • Vaginal discomfort/pain
    5%
  • Arthritis
    4%
  • Trouble sleeping
    4%
  • Stomach pain
    4%
  • Sinus infection
    4%
  • Vaginal bleeding
    4%
  • Bacterial growth in the genitals
    4%
  • Joint pain
    3%
  • Nausea
    3%
  • Flu-like symptoms
    3%
  • Bone pain
    2%
  • Bladder infection
    2%
  • Hot flashes
    2%
  • Stress
    2%
See more detailed side effects
5possible side effects
  • Headache
    7%
  • Breast tenderness
    4%
  • Nasopharyngitis (common cold)
    4%
  • Nipple pain
    2%
  • Back pain
    2%
See more detailed side effects
Risks and risk factors
  • Uterine cancer
    • Using estrogen for more than one year
    • Higher dose of estrogen
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen and progestin for more than one year
  • Blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Inflammation of pancreas (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Duration of use
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Harm to fetus
    • Women of childbearing age
  • Early puberty in children
See more detailed risks and warnings
Learn more about Estring (estradiol vaginal ring)
Learn more about Evamist (Estradiol Spray)