Compare Estring vs. Premarin vaginal cream
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Relieves vaginal dryness due to menopause.
Estring (estradiol vaginal ring) is more convenient than other forms of estrogen therapy since you only have to replace it every 3 months, but it needs to be inserted directly into the vagina.
●●●●●
3.3/ 5 average rating with 56 reviewsforEstring
Relieves vaginal dryness and pain during sex due to menopause.
Premarin vaginal cream (conjugated estrogens) has less side-effects than estrogen pills, but only works for localized symptoms of menopause.
Upsides
- Many women find Estring (estradiol vaginal ring) more comfortable to use and easier to apply than creams or gels.
- Estring (estradiol vaginal ring) may be more convenient since it is dosed once every 3 months compared to alternatives that need to taken daily or twice weekly.
- Works directly at the site of application and safer than oral estrogen pills.
- Works locally in the vagina, so it has less side effects than estrogen pills.
- Works better than over-the-counter lubricants to relieve pain during sex caused by menopause.
- Can be dosed twice a week to relieve painful sex due to menopause.
Downsides
- Estring (estradiol vaginal ring) may not be the best option if you have a narrow vagina or frequent vaginal infections.
- The ring can fall out without you noticing.
- Estring (estradiol vaginal ring) is only available as brand name, so can be expensive.
- Estring (estradiol vaginal ring) All estrogen therapies increase your risk for uterine cancer, heart problems, and blood clots.
- Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphragms. Do not rely on these methods to protect against sexually transmitted infections for up to 72 hours after using Premarin vaginal cream (conjugated estrogens).
- Premarin vaginal cream (conjugated estrogens) increases risk of uterine cancer so women with intact uterus should not use it by itself.
- Available as a branded product only, so it may be expensive.
Used for
- Vaginal dryness and inflammation
- Vaginal dryness and inflammation due to menopause
- Painful sex due to menopause
Dosage forms
- Vaginal ring
- Cream
Price
Lowest price
$439.07
Find instant savings near youLowest price
$159.08
Find instant savings near youWant to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Reviews
56 reviews so far
63%
saidit'sworth it
39%
saiditworked well
18%
saidit'sa big hassle
Have you used Estring (estradiol vaginal ring)?
Leave a reviewNot enough review data.Leave a review
Side effects
20possible side effects
- Headache13%
- Vaginal discharge7%
- Back pain6%
- Yeast infection6%
- Upper airway infection5%
- Vaginal inflammation5%
- Vaginal discomfort/pain5%
- Arthritis4%
- Trouble sleeping4%
- Stomach pain4%
- Sinus infection4%
- Vaginal bleeding4%
- Bacterial growth in the genitals4%
- Joint pain3%
- Nausea3%
- Flu-like symptoms3%
- Bone pain2%
- Bladder infection2%
- Hot flashes2%
- Stress2%
6possible side effects
- Pelvic pain3%
- Vaginal discharge3%
- Headache2%
- Breast pain2%
- Vaginal inflammation2%
- Other problems with the vagina or vulva2%
Risks and risk factors
- Uterine cancer
- Using estrogen for more than one year
- Higher dose of estrogen
- Breast cancer
- Personal or family history of breast cancer
- Using estrogen and progestin for more than one year
- Blood clots and stroke
- Personal or family history of blood clots
- Smoking
- Obesity
- Systemic lupus erythematosus (SLE)
- Heart disease
- Smoking
- Obesity
- High blood pressure
- High blood sugar
- High cholesterol
- Age 50 or older
- Dementia
- Age 65 or older
- Inflammation of pancreas (pancreatitis)
- High levels of triglycerides
- Endometrial cancer
- Using estrogen for more than one year
- Higher dose of estrogen
- Breast cancer
- Personal or family history of breast cancer
- Using estrogen and progestin for more than one year
- Increased risk of blood clots and stroke
- Personal or family history of blood clots
- Smoking
- Obesity
- Systemic lupus erythematosus (SLE)
- Increased risk of heart disease
- Smoking
- Obesity
- High blood pressure
- High blood sugar
- High cholesterol
- Age 50 or older
- Dementia
- Age 65 or older
- Pancreas swelling (pancreatitis)
- High levels of triglycerides