Compare Estrogel vs. Prefest

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Relieves hot flashes and vaginal dryness due to menopause.

Estrogel (Estradiol) is a topical gel that can relieve both vaginal dryness and hot flashes, but needs to be applied across the length your entire arm.

3.2/ 5 average rating with 78 reviewsforEstrogel
Relieves menopause symptoms and lowers your risk of osteoporosis.

Prefest (Estradiol / Norgestimate) is effective at treating symptoms related to menopause and bone loss. It has a difficult dosing schedule to follow, but doesn't affect your cholesterol and triglyceride levels as much as other estrogen products.

Upsides
  • The pump is easy to use and comes in two different bottle sizes.
  • Good alternative if you don't want to take estrogen pills.
  • Prefest (Estradiol / Norgestimate) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Good for women with an intact uterus. The norgestimate (a progestin) protects against the risk of cancer in the uterus caused by estrogen treatment.
  • Doesn't affect your cholesterol levels as much as other estrogen treatments.
Downsides
  • Available as brand name product only so it may be expensive.
  • Directions for application can be messy and hard to follow.
  • You may unknowingly expose others to the medicine through skin contact.
  • All estrogen replacement therapies are associated with serious side-effects like blood clots, uterine cancer, and breast cancer. You will need to thoroughly discuss the risks and benefits with your doctor before starting treatment.
  • More potential side effects since it exposes your whole body to two hormones, estrogen and norgestimate (a progestin).
  • Dosing schedule can be hard to follow with the 2 different kind of pills (estrogen-only and estrogen/progestin pills).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
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Used for
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Prevention of postmenopausal osteoporosis
Dosage forms
  • Gel
  • Pill
Price
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Reviews
78 reviews so far
45%
saidit'sworth it
28%
saiditworked well
10%
saidit'sa big hassle

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Side effects
3possible side effects
  • Breast pain
    11%
  • Headache
    10%
  • Gas
    5%
See more detailed side effects
22possible side effects
  • Headache
    23%
  • Upper respiratory-tract infection
    21%
  • Breast pain
    16%
  • Back pain
    12%
  • Abdominal pain
    12%
  • Influenza-like symptoms
    11%
  • Arthralgia
    9%
  • Vaginal bleeding (all)
    9%
  • Dysmenorrhea
    8%
  • Sinusitis
    8%
  • Vaginitis
    7%
  • Pharyngitis
    7%
  • Fatigue
    6%
  • Pain
    6%
  • Nausea
    6%
  • Viral infection
    6%
  • Flatulence
    5%
  • Tooth disorder
    5%
  • Myalgia
    5%
  • Dizziness
    5%
  • Depression
    5%
  • Coughing
    5%
See more detailed side effects
Risks and risk factors
  • Uterine cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Inflammation of pancreas
    • High levels of triglycerides
See more detailed risks and warnings
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Duration of use
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Harm to fetus
    • Women of childbearing age
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
  • Ovarian cancer
    • Family history of ovarian cancer
See more detailed risks and warnings