Compare Fanapt vs. Saphris

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Fanapt (Iloperidone)

Prescription only

Saphris (asenapine)

Prescription only
Controls schizophrenia.

Fanapt (Iloperidone) is helpful for treating schizophrenia, but it can be expensive because it's only available as brand name.

Treats bipolar disorder and schizophrenia.

While Saphris (asenapine) has fewer side effects compared with other medicines that treat bipolar disorder and schizophrenia, it can be more expensive.

Upsides
  • Part of the first choice medications to treat schizophrenia.
  • There are patient assistance programs that can lower the copay.
  • Comes in many different strengths to make it easier to customize your dose.
  • Less likely to cause sexual problems than other similar medicines.
  • Saphris (asenapine) can be used to treat bipolar disorder in children age 10 or older, and schizophrenia in children age 12 or older.
  • You don't need water to take Saphris (asenapine); the pill dissolves in your mouth right away.
  • Compared to other medicines, the side effects of Saphris (asenapine) are milder.
Downsides
  • Fanapt (Iloperidone) can be expensive because it is only available as brand name.
  • You will need to follow a strict schedule the first two weeks as body adjusts to Fanapt (Iloperidone). You might have to see your doctor several times until you find a dose that works best for you.
  • You're more likely to have changes in blood pressure with Fanapt (Iloperidone), which can make you feel faint or dizzy.
  • If you stop taking Fanapt (Iloperidone) for 3 days and want to restart it, you'll have to start taking it from the beginning dose.
  • You have to take Fanapt (Iloperidone) twice a day, which can be hard to remember.
  • Saphris (asenapine) is only available as a brand name.
  • Compared to other medicines, Saphris (asenapine) can cause changes in your hormones and make you sleepy.
  • You have to take Saphris (asenapine) twice a day, which can be hard to remember.
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Used for
Dosage forms
  • Pill
  • Dissolving pill
Price
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Reviews
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Side effects
20possible side effects
  • Dizziness
    10%
  • Sleepiness
    9%
  • Dry mouth
    8%
  • Nausea
    7%
  • Diarrhea
    5%
  • Difficulty controlling movements
    5%
  • Agitation
    5%
  • Nasal congestion
    5%
  • Fatigue
    4%
  • Sore throat
    4%
  • Joint pain
    3%
  • Faster heart rate
    3%
  • Blurred vision
    3%
  • Tremor
    3%
  • Sluggishness
    3%
  • Rash
    3%
  • Sudden changes in blood pressure
    3%
  • Colds or flu
    2%
  • Ejaculation disorder
    2%
  • Difficulty breathing
    2%
See more detailed side effects
10possible side effects
  • Sleepiness
    22%
  • Trouble sleeping
    10%
  • Difficulty controlling movements
    6%
  • Numbness in the mouth
    5%
  • Fatigue
    4%
  • Dizziness
    4%
  • Indigestion
    3%
  • Swelling in the arms and legs
    3%
  • Weight gain
    3%
  • High blood pressure
    3%
See more detailed side effects
Risks and risk factors
  • Increased risk of death
    • People over 65 with dementia and psychosis
  • Neuroleptic malignant syndrome
    • Taking antipsychotic medications
  • Higher blood sugar, cholesterol, and weight gain
    • People with diabetes
    • People with high cholesterol
  • Difficulty controlling movements
    • Long-term use of atypical antipsychotics
  • Blood disorders
  • Changes in blood pressure and heart beat
    • High blood pressure
    • History of heartbeat problems
See more detailed risks and warnings
  • Higher risk of death
    • People age 65 or older with dementia and psychosis
  • Neuroleptic malignant syndrome
    • Taking antipsychotic medications
  • Difficulty controlling movements
  • Weight gain and diabetes
  • Changes in blood pressure and fainting
    • High blood pressure
    • History of heart disease
  • Higher risk of infection
See more detailed risks and warnings