Compare Farxiga vs. Afrezza

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Farxiga (dapagliflozin)

Prescription only

Afrezza (insulin)

Prescription only
Lowers blood sugar.

Farxiga (dapagliflozin) can be used together with other diabetes medicines to help lower your blood sugar, but it can be expensive because it's brand name.

Controls mealtime blood sugar.

Afrezza (insulin) is effective at controlling blood sugar, but you can't use it if you've had lung problems or smoke.

Upsides
  • Can lower A1c by 1% (A1c measures your average blood sugar over time.)
  • Can help you lose weight.
  • Less chance of low blood sugar than other diabetes medicines.
  • Afrezza (insulin) is as effective as other mealtime insulin products.
  • Starts working faster and stays in your body for a shorter time than other mealtime insulin products, so you're less likely to have severely low blood sugar.
  • If you don't like needles, Afrezza (insulin) is a good alternative since you inhale it.
  • Safe to use in people 65 or older.
  • Talk to your doctor or pharmacist about ways to lower your copay, such as coupons.
Downsides
  • Not a first choice medicine for diabetes because it doesn't lower blood sugar as much as other medicines.
  • Higher risk of genital yeast infections and urinary tract infections.
  • This is an expensive medication with no generic available at this time.
  • Not shown to improve cardiovascular outcomes like other similar medicines because it can increase cholesterol.
  • Not a good choice if you drink a lot of alcohol.
  • Not recommended if you're a smoker or if you've smoked in the last 6 months.
  • Afrezza (insulin) only comes in 3 different strengths, so it can be inconvenient if you need a lot of insulin.
  • Not recommended in children under 18.
  • If you're pregnant, you'll need to talk to your doctor before you start Afrezza (insulin).
  • There is no generic available, and may not be covered right away by Medicare or other insurances.
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Used for
Dosage forms
  • Pill
  • Inhalation powder
Price
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Reviews
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Side effects
13possible side effects
  • Female yeast infection
    8%
  • Common cold symptoms
    7%
  • Urinary tract infection
    6%
  • Back pain
    3%
  • Increased urination
    3%
  • Male yeast infection
    3%
  • Nausea
    3%
  • Flu
    3%
  • Increased cholesterol
    2%
  • Constipation
    2%
  • Discomfort with urination
    2%
  • Pain in hands and feet
    2%
  • Mild low blood sugar
    2%
See more detailed side effects
6possible side effects
  • Cough
    28%
  • Throat pain or irritation
    6%
  • Headache
    5%
  • Worsening lung function test
    3%
  • Airway inflammation
    3%
  • Urinary tract infection
    2%
See more detailed side effects
Risks and risk factors
  • Genital yeast infection
  • Urinary tract infection
  • Low blood pressure
    • Taking water pills for blood pressure
    • Over age 65
    • Kidney problems
  • Kidney problems
    • Kidney damage
    • Taking water pills, ACE inhibitors or ARBs for blood pressure
    • Anti-inflammatory medicines (NSAIDs)
    • Heart failure
  • Increased acid and ketones in the blood
    • Long periods of fasting
    • Alcohol abuse
    • Dehydration
    • History of pancreatitis
See more detailed risks and warnings
  • Low blood sugar
    • Changes in diet and exercise
    • Drinking alcohol
    • Taking other medications for diabetes
    • Over age 65
    • Liver or kidney problems
  • Breathing problems
    • Asthma
    • Chronic Obstructive Pulmonary Disease (COPD)
    • Other long term lung problems
  • Low blood potassium levels
    • Taking laxatives
    • Taking medications that increase urination
  • Worsening lung function
    • Smoking
    • Second-hand smoke
    • Indoor and outdoor pollution
    • Work-related fume and chemical exposure
  • Fluid buildup
    • Taking Avandia or Actos
  • Too much acid in the blood
    • Type 1 diabetes
    • Long periods of fasting
    • Alchohol abuse
    • History of pancreatitis
See more detailed risks and warnings