Compare Fioricet vs. Zomig

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats tension headaches.

Fioricet (Butalbital / Acetaminophen / Caffeine) works well for tension headaches, but isn’t recommended due to the ability to overuse it and have withdrawal symptoms.

4.3/ 5 average rating with 17 reviewsforFioricet
Treats migraines.

Triptans are the first-choice to treat migraines. Zomig (zolmitriptan) works just as well as other triptans for migraines.

Upsides
  • Fioricet (Butalbital / Acetaminophen / Caffeine) works better and faster in treating tension headaches than the combination of acetaminophen and codeine.
  • Fioricet (Butalbital / Acetaminophen / Caffeine) doesn’t cost much since it's available as a generic medication.
  • Fioricet (Butalbital / Acetaminophen / Caffeine) has very few side effects.
  • It has been widely used for a long time.
  • Zomig (zolmitriptan) is is a first choice treatment to treat severe migraines.
  • There are different forms of Zomig (zolmitriptan) available, including a dissolving pill and a nasal spray if you have trouble swallowing during a migraine attack.
  • The regular and dissolving pill forms of Zomig (zolmitriptan) are available as generics.
Downsides
  • Fioricet (Butalbital / Acetaminophen / Caffeine) isn't the first choice medication for treating tension headaches.
  • It's not a good medication for long-term use.
  • Overuse of Fioricet (Butalbital / Acetaminophen / Caffeine) can lead to chronic tension headaches.
  • Fioricet (Butalbital / Acetaminophen / Caffeine) can cause dangerous withdrawal symptoms, intoxication, and dependence.
  • Taking Fioricet (Butalbital / Acetaminophen / Caffeine) can decrease your ability to drive a car, or operate machinery.
  • If you're taking the nasal spray form of Zomig (zolmitriptan), you have to follow the instructions exactly or you won't get the full dose of medicine.
  • The nasal spray form of Zomig (zolmitriptan) is only available as brand name, so it can be expensive.
  • If you have heart disease or history of stroke, Zomig (zolmitriptan) may not be the best choice for you. Talk to your doctor about your medical history.
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Used for
Dosage forms
  • Pill
  • Oral solution
  • Pill
  • Dissolving tablet
  • Nasal spray
Price
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Reviews
17 reviews so far
88%
saidit'sworth it
76%
saiditworked well
12%
saidit'sa big hassle

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Side effects
The Fioricet (Butalbital / Acetaminophen / Caffeine) FDA package insert doesn’t have numbers about how common side effects are.
12possible side effects
  • Changes in taste
    21%
  • Tingling or prickling sensation
    10%
  • Oversensitivity of the skin
    5%
  • Pain
    4%
  • Pain in the throat
    4%
  • Nausea
    4%
  • Sleepiness
    4%
  • Discomfort in the nose
    3%
  • Dizziness
    3%
  • Weakness
    3%
  • Tightness in the throat
    2%
  • Dry mouth
    2%
See more detailed side effects
Risks and risk factors
  • Liver damage
    • Drinking more than 2 alcoholic beverages a day
    • Taking with other acetaminophen-containing medicines
    • History of liver disease
  • Hypersensitivity (allergic) reactions
See more detailed risks and warnings
  • Heart attack
    • Heart disease
    • history of chest pain/angina
    • uncontrolled high blood pressure
  • Stroke
    • History of a stroke
  • Medication overuse headache
    • Using Zomig (zolmitriptan) or other migraine treatment medications for 10 or more days a month
  • Changes in heartbeat
    • History of arrhythmia
  • Serotonin syndrome
    • Taking tricyclic antidepressants, fentanyl, tramadol, buspirone, or ADHD medicines
  • Blood vessel issues
    • High blood pressure
    • history of stroke
See more detailed risks and warnings