Compare Flexeril vs. chlorzoxazone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Relaxes your muscles.

Flexeril (cyclobenzaprine) is widely used to treat muscle spasms and is available as a generic, but it shouldn't be used long-term.

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3.5/ 5 average rating with 1064 reviewsforFlexeril
Relieves muscle pain caused by spasms.

While Parafon Forte DSC (chlorzoxazone) can be used to treat muscle pain, it can have bad side effects.

Upsides
  • Can relieve pain associated with muscle spasms.
  • Available as a generic medication.
  • Can be used by pregnant women, but talk to your doctor about it first.
  • Parafon Forte DSC (chlorzoxazone) works just as well as other medicines used for muscle pain caused by spasms.
  • Parafon Forte DSC (chlorzoxazone) is available in generic.
Downsides
  • Can cause dizziness and sleepiness.
  • Not meant for long-term therapy.
  • Not recommended in elderly patients, people with glaucoma, or in people with heart conditions (like rhythm problems, heart failure, or recent heart attack).
  • Can make you have dry mouth.
  • Not effective for muscle spasms caused by brain or spinal injuries.
  • For muscle pain such as back or neck pain, anti-inflammatory medicines like ibuprofen or naproxen are preferred over Parafon Forte DSC (chlorzoxazone).
  • Parafon Forte DSC (chlorzoxazone) is not recommended if you're over 65 because it can make you more sleepy and more likely to break your bones.
  • Parafon Forte DSC (chlorzoxazone) works best with physical therapy and rest.
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Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
Price
Lowest price
$214.28
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Lowest price
$206.25
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Reviews
1064 reviews so far
66%
saidit'sworth it
37%
saiditworked well
14%
saidit'sa big hassle

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Side effects
4possible side effects
  • Dry mouth
    6%
  • Dizziness
    3%
  • Fatigue
    3%
  • Nausea
    3%
See more detailed side effects
The Parafon Forte DSC (chlorzoxazone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Serotonin syndrome
    • Taking monoamine oxidase inhibitors (MAOI)
    • Taking other medications for your mood
  • Dizziness and sleepiness
    • Alcohol or drug use
    • Age over 65 years
  • Heart attack or stroke
    • Recent heart attack
    • Heart rhythm problems
    • Heart failure
  • Dehydration
    • Older than 65 years
    • Dehydration
  • Overactive Thyroid
    • Overactive thyroid
See more detailed risks and warnings
  • Liver damage
    • Taking acetaminophen (Tylenol) with Parafon Forte DSC (chlorzoxazone)
  • Central nervous system depression
    • Alcohol
    • Taking narcotics, tranquilizers or antihistamines
  • Skin rashes
    • Allergies to muscle relaxants
See more detailed risks and warnings
Learn more about Flexeril (cyclobenzaprine)
Learn more about Parafon Forte DSC (chlorzoxazone)