Compare Flexeril vs. Gablofen

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Gablofen (baclofen)

Prescription only
Relaxes your muscles.

Flexeril (cyclobenzaprine) is widely used to treat muscle spasms and is available as a generic, but it shouldn't be used long-term.

3.5/ 5 average rating with 1064 reviewsforFlexeril
Works well to control muscle spasticity.

Gablofen (baclofen) is effective for long term spastic conditions, such as multiple sclerosis, spinal cord injury, and others. It is administered intrathecally by a pump connecting to your spine.

Upsides
  • Can relieve pain associated with muscle spasms.
  • Available as a generic medication.
  • Can be used by pregnant women, but talk to your doctor about it first.
  • Gablofen (baclofen) is the agent of choice for treatment of muscle spasticity.
  • Gablofen (baclofen) has fewer side effects than the oral form, since higher levels can be delivered to the spine at lower doses.
Downsides
  • Can cause dizziness and sleepiness.
  • Not meant for long-term therapy.
  • Not recommended in elderly patients, people with glaucoma, or in people with heart conditions (like rhythm problems, heart failure, or recent heart attack).
  • Can make you have dry mouth.
  • Not effective for muscle spasms caused by brain or spinal injuries.
  • Gablofen (baclofen) can cause sleepiness and drowsiness.
  • Stopping Gablofen (baclofen) right away can be life-threatening, so a doctor would need to help you stop it.
  • Gablofen (baclofen) has to be started in the doctor's office. You or your caregiver need to be trained on how to use the pump.
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Used for
Dosage forms
  • Pill
  • Liquid
  • Injection
Price
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Reviews
1064 reviews so far
66%
saidit'sworth it
37%
saiditworked well
14%
saidit'sa big hassle

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Side effects
4possible side effects
  • Dry mouth
    6%
  • Dizziness
    3%
  • Fatigue
    3%
  • Nausea
    3%
See more detailed side effects
21possible side effects
  • Loss of muscle tone
    35%
  • Drowsiness
    19%
  • Headache
    11%
  • Convulsion
    10%
  • Urinary Retention
    8%
  • Dizziness
    8%
  • Nausea
    7%
  • Increased muscle tone
    6%
  • Vomiting
    4%
  • Slowed breathing
    4%
  • Pain
    4%
  • Itchiness
    4%
  • Increased salivation
    3%
  • Swelling of limbs
    3%
  • Back pain
    2%
  • Constipaiton
    2%
  • Diarrhea
    2%
  • Weak muscles
    2%
  • Pneumonia
    2%
  • Urination control problems
    2%
  • Inability to urinate
    2%
See more detailed side effects
Risks and risk factors
  • Serotonin syndrome
    • Taking monoamine oxidase inhibitors (MAOI)
    • Taking other medications for your mood
  • Dizziness and sleepiness
    • Alcohol or drug use
    • Age over 65 years
  • Heart attack or stroke
    • Recent heart attack
    • Heart rhythm problems
    • Heart failure
  • Dehydration
    • Older than 65 years
    • Dehydration
  • Overactive Thyroid
    • Overactive thyroid
See more detailed risks and warnings
  • Withdrawal symptoms
    • Stopping Gablofen (baclofen) too quickly
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
  • Seizures
    • Higher dose
    • Using other medicines that can cause seizures
    • History of seizures
    • Alcoholism
    • Eating disorders
    • Brain infections
See more detailed risks and warnings