Compare Flexeril vs. Norflex

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Norflex (orphenadrine)

Prescription only
Relaxes your muscles.

Flexeril (cyclobenzaprine) is widely used to treat muscle spasms and is available as a generic, but it shouldn't be used long-term.

3.5/ 5 average rating with 1064 reviewsforFlexeril
Relaxes your muscles.

Norflex (orphenadrine) can be used for relaxing muscle spasms and it also can relieve pain.

  • Can relieve pain associated with muscle spasms.
  • Available as a generic medication.
  • Can be used by pregnant women, but talk to your doctor about it first.
  • More effective than placebo for treatment of muscle spasms and nonspecific musculoskeletal pain in the short term.
  • Extended release pills last 12 hours.
  • Available as generic.
  • Can cause dizziness and sleepiness.
  • Not meant for long-term therapy.
  • Not recommended in elderly patients, people with glaucoma, or in people with heart conditions (like rhythm problems, heart failure, or recent heart attack).
  • Can make you have dry mouth.
  • Not effective for muscle spasms caused by brain or spinal injuries.
  • Not a first choice treatment for muscle spasms.
  • Norflex (orphenadrine) can make you sleepy or drowsy.
  • At higher doses, Norflex (orphenadrine) can make you confused or hallucinate.
  • Dry mouth and difficulty urinating can happen at higher doses.
  • Pills cannot be crushed and must be swallowed whole.
  • Can't be used in people with glaucoma, certain types of bowel obstruction or peptic ulcers, prostatic hypertrophy, certain urinary problems, cardio-spasm (megaesophagus) and myasthenia gravis.
Used for
Dosage forms
  • Pill
  • Liquid
  • Extended release pill
  • Pill
  • Injection
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1064 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

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Side effects
4possible side effects
  • Dry mouth
  • Dizziness
  • Fatigue
  • Nausea
See more detailed side effects
The Norflex (orphenadrine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Serotonin syndrome
    • Taking monoamine oxidase inhibitors (MAOI)
    • Taking other medications for your mood
  • Dizziness and sleepiness
    • Alcohol or drug use
    • Age over 65 years
  • Heart attack or stroke
    • Recent heart attack
    • Heart rhythm problems
    • Heart failure
  • Dehydration
    • Older than 65 years
    • Dehydration
  • Overactive Thyroid
    • Overactive thyroid
See more detailed risks and warnings
  • Sleepiness and dizziness
    • Taking other medications that also cause sleepiness
    • Recreational drug use
    • Excessive alcohol use
  • Abuse, dependence and withdrawal
    • Prior history of drug abuse
  • Heart problems
    • History of fast or irregular heartbeat
    • History of heart failure or other heart problems
See more detailed risks and warnings