Compare Flexeril vs. Zanaflex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Zanaflex (tizanidine)

Prescription only
Relaxes your muscles.

Flexeril (cyclobenzaprine) is widely used to treat muscle spasms and is available as a generic, but it shouldn't be used long-term.

3.5/ 5 average rating with 1064 reviewsforFlexeril
Relaxes your muscles.

Zanaflex (tizanidine) isn't a first-choice treatment for muscle spasticity. Try other options before using this.

4.3/ 5 average rating with 26 reviewsforZanaflex
Upsides
  • Can relieve pain associated with muscle spasms.
  • Available as a generic medication.
  • Can be used by pregnant women, but talk to your doctor about it first.
  • Relieves muscle spasticity.
  • Available as a generic.
  • Available in a tablet or capsule form. It also comes in a capsule that can be opened and sprinkled in applesauce for people that can't swallow pills.
Downsides
  • Can cause dizziness and sleepiness.
  • Not meant for long-term therapy.
  • Not recommended in elderly patients, people with glaucoma, or in people with heart conditions (like rhythm problems, heart failure, or recent heart attack).
  • Can make you have dry mouth.
  • Not effective for muscle spasms caused by brain or spinal injuries.
  • This isn't a first-choice muscle relaxing medication. Other drugs work better and have fewer side effects.
  • Takes over an hour to kick in and only lasts 3 to 6 hours.
  • Zanaflex (tizanidine) can lower blood pressure, so be careful if you are already on a blood pressure medication.
  • Need to be consistent every day in taking this with or without food.
  • Elderly individuals have more side effects when taking Zanaflex (tizanidine).
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Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
Price
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Reviews
1064 reviews so far
66%
saidit'sworth it
37%
saiditworked well
14%
saidit'sa big hassle

Have you used Flexeril (cyclobenzaprine)?

Leave a review
26 reviews so far
81%
saidit'sworth it
73%
saiditworked well
19%
saidit'sa big hassle

Have you used Zanaflex (tizanidine)?

Leave a review
Side effects
4possible side effects
  • Dry mouth
    6%
  • Dizziness
    3%
  • Fatigue
    3%
  • Nausea
    3%
See more detailed side effects
17possible side effects
  • Dry mouth
    49%
  • Sleepiness
    48%
  • Weakness
    41%
  • Dizziness
    16%
  • Urinary tract infection
    10%
  • General infection
    6%
  • Liver test abnormality
    6%
  • Constipation
    4%
  • Vomiting
    3%
  • Speech disorder
    3%
  • Blurred vision
    3%
  • Urinary frequency
    3%
  • Flu syndrome
    3%
  • Involuntary muscle movement
    3%
  • Nervousness
    3%
  • Sore throat
    3%
  • Hay fever
    3%
See more detailed side effects
Risks and risk factors
  • Serotonin syndrome
    • Taking monoamine oxidase inhibitors (MAOI)
    • Taking other medications for your mood
  • Dizziness and sleepiness
    • Alcohol or drug use
    • Age over 65 years
  • Heart attack or stroke
    • Recent heart attack
    • Heart rhythm problems
    • Heart failure
  • Dehydration
    • Older than 65 years
    • Dehydration
  • Overactive Thyroid
    • Overactive thyroid
See more detailed risks and warnings
  • Liver damage
    • Taking maximum doses of Zanaflex (tizanidine)
  • Dizziness and low blood pressure
    • Age 65 years or older
    • Currently on blood pressure control medications
  • Sleepiness and driving impairment
    • Taking other medications that also cause sleepiness
    • Recreational drug use
    • Excessive alcohol use
    • Elderly
  • Withdrawal side effects
    • Stopping Zanaflex (tizanidine) suddenly
See more detailed risks and warnings