Compare fluphenazine vs. thiothixene

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Prolixin (fluphenazine)

Prescription only

Navane (thiothixene)

Prescription only
Treats schizophrenia and psychosis.

Prolixin (fluphenazine) can stabilize your mood. It is used to find the right dose for you before moving to a long-acting injection.

Treats schizophrenia.

Navane (thiothixene) isn't a first choice for treating schizophrenia because of the side effects, but it is cheaper than other medicines.

Upsides
  • Good at stabilizing your mood.
  • Available in several oral and injectable forms, including a long-acting injection that is taken less frequently.
  • Navane (thiothixene) is available in generic.
  • Navane (thiothixene) is less likely to make you sleepy.
Downsides
  • Can make you sensitive to the sun.
  • Can affect how your body regulates your temperature.
  • Can make it difficult for you to control your movements if you've been on Prolixin (fluphenazine) for a while.
  • Side effects include weight gain and high blood sugar.
  • Navane (thiothixene) can cause low blood pressure, which can cause fainting or falls if you’re not careful.
  • Smoking tobacco can make Navane (thiothixene) work poorly.
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Used for
Dosage forms
  • Pill
  • Liquid
  • Injection
  • Pill
Price
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Reviews
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Side effects
The Prolixin (fluphenazine) FDA package insert doesn’t have numbers about how common side effects are.
The Navane (thiothixene) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Increased risk of death
    • People over 65 with dementia and psychosis
  • Difficulty controlling movements
  • Neuroleptic malignant syndrome
    • Taking antipsychotic medications
  • Low white blood cell count
See more detailed risks and warnings
  • Higher risk of death
    • People age 65 or older with dementia and psychosis
  • Difficulty controlling movements
  • Neuroleptic malignant syndrome
  • Drowsiness and sleepiness
    • Drinking alcohol, or taking opioids, benzodiazepines, or sleeping medicines
  • Low blood pressure
See more detailed risks and warnings