Compare Fosamax vs. Estrace

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Fosamax (alendronate)

Prescription only

Estrace (Estradiol)

Prescription only
Prevents bone loss.

Fosamax (alendronate) is a first-choice treatment for osteoporosis, but taking it can be a hassle.

3.2/ 5 average rating with 169 reviewsforFosamax
Relieves hot flashes and vaginal symptoms related to menopause.

Estrace (Estradiol) treats symptoms of menopause, but causes more of side effects than other medicines like it.

  • First choice to treat osteoporosis
  • Lowers your risk of fractures due to osteoporosis.
  • Available generic.
  • Available as daily, weekly, or twice weekly dosing.
  • Comes as a regular tablet, an oral solution, or effervescent tablet.
  • Estrace (Estradiol) comes as a pill and is much easier to use compared to the cream form.
  • Available as a cheaper, generic version.
  • Usually you only need to take DRUG NAME for a short amount of time.
  • Can harm your esophagus if you don't remain upright for 30 minutes after taking it.
  • Not recommended for people who can't sit or stand upright for at least 30 minutes.
  • Can increase the risk of atypical fractures.
  • Can cause bad heartburn or stomach problems.
  • Associated with a higher risk for side effects like blood clots, stroke, and cancer compared to its cream formulation.
  • DRUG_ NAME can increase the risk of memory loss for women age 65 or older.
  • Your doctor might frequently change your dose of the medicine in the beginning until your symptoms are well-controlled.
  • Not recommended for women who need treatment only for vaginal dryness and itching.
Used for
  • Hot flashes
  • Vaginal dryness and inflammation
  • Low estrogen
  • Primary ovarian failure
  • Prevention of postmenopausal osteoporosis
  • Metastatic breast cancer
  • Advanced prostate cancer
Dosage forms
  • Pill
  • Effervescent tablet
  • Liquid
  • Pill
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
169 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

Have you used Fosamax (alendronate)?

Leave a review
Not enough review data.Leave a review
Side effects
1possible side effects
  • Abdominal pain
See more detailed side effects
The Estrace (Estradiol) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Irritation and ulcers to the stomach and esophagus
    • Taking anti-inflammatory medicines like ibuprofen, and naproxen
    • History of ulcers or stomach or esophageal conditions
    • Difficulty swallowing
    • Problems sitting or standing for at least 30 minutes
  • Pain in the bones and muscles
  • Problems in the jaw bone
    • Oral or dental surgery
    • Cancer
    • Poor oral hygiene
    • Prolonged use of Fosamax (alendronate)
  • Leg bone fractures
  • Low calcium in the blood
See more detailed risks and warnings
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Inflammation of pancreas
    • High levels of triglycerides
See more detailed risks and warnings