Compare Fosamax vs. Evista

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Fosamax (alendronate)

Prescription only

Evista (raloxifene)

Prescription only
Prevents bone loss.

Fosamax (alendronate) is a first-choice treatment for osteoporosis, but taking it can be a hassle.

3.2/ 5 average rating with 169 reviewsforFosamax
Prevents bone loss and lowers your risk of invasive breast cancer.

Evista (raloxifene) helps to reduce bone loss and lower the risk of breast cancer in post-menopausal women, but it can cause blood clots.

Upsides
  • First choice to treat osteoporosis
  • Lowers your risk of fractures due to osteoporosis.
  • Available generic.
  • Available as daily, weekly, or twice weekly dosing.
  • Comes as a regular tablet, an oral solution, or effervescent tablet.
  • Evista (raloxifene) is a good choice for prevention of bone loss for postmenopausal women. Evista (raloxifene) can also reduce your risk for invasive breast cancer.
  • Unlike bisphosphonates, Evista (raloxifene) is easier on your stomach.
  • Although Evista (raloxifene) acts like estrogen, it doesn't increase the chances of uterine or breast cancer.
  • If you are having hot flashes, Evista (raloxifene) may help relieve them, unlike some alternatives.
Downsides
  • Can harm your esophagus if you don't remain upright for 30 minutes after taking it.
  • Not recommended for people who can't sit or stand upright for at least 30 minutes.
  • Can increase the risk of atypical fractures.
  • Can cause bad heartburn or stomach problems.
  • Evista (raloxifene) can cause side effects similar to estrogen such as clots and hot flashes, which doesn't happen with bisphosphonate alternatives like Fosamax (alendronate).
  • Premenopausal women cannot take Evista (raloxifene) for breast cancer prevention.
  • It is not the first choice treatment for osteoporosis unless you cannot take bisphosphonates.
  • Your doctor may ask you to take this medicine for years to prevent bone loss.
  • If you are on a blood-thinner called warfarin, you may need to do a blood test before starting this medicine.
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Used for
  • Post-menopausal osteoporosis
  • Breast cancer prevention
Dosage forms
  • Pill
  • Effervescent tablet
  • Liquid
  • Pill
Price
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Reviews
169 reviews so far
43%
saidit'sworth it
30%
saiditworked well
19%
saidit'sa big hassle

Have you used Fosamax (alendronate)?

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Side effects
1possible side effects
  • Abdominal pain
    2%
See more detailed side effects
45possible side effects
  • Hot flashes
    25%
  • Joint pain
    16%
  • Flu-like symptoms
    15%
  • Infection
    11%
  • Stuffy nose
    10%
  • Difficulty breathing
    10%
  • Sinus infection
    10%
  • Headache
    9%
  • Increased cough
    9%
  • Nausea
    9%
  • Weight gain
    9%
  • Muscle pain
    8%
  • Sore throat
    8%
  • Leg cramps
    7%
  • Diarrhea
    7%
  • Stomach pain
    7%
  • Indigestion
    6%
  • Depression
    6%
  • Difficulty sleeping
    6%
  • Rash
    6%
  • Vaginal bleeding
    6%
  • Vomiting
    5%
  • Swelling
    5%
  • Fever
    4%
  • Tendon disorder
    4%
  • Vertigo
    4%
  • Chest pain
    4%
  • Arthritis
    4%
  • Bladder infection
    4%
  • Breast Pain
    4%
  • Sweating
    3%
  • Uterine disorder
    3%
  • Urinary tract disorder
    3%
  • Flatulence
    3%
  • Stomach and intestinal disorders
    3%
  • Stomach flu
    3%
  • Swelling in arms or legs
    3%
  • Pneumonia
    3%
  • Vaginal discharge
    3%
  • Endometrial disorder
    3%
  • Fainting
    2%
  • Stabbing nerve pain
    2%
  • Pink eye
    2%
  • Migraine
    2%
  • Inflamed vocal cords
    2%
See more detailed side effects
Risks and risk factors
  • Irritation and ulcers to the stomach and esophagus
    • Taking anti-inflammatory medicines like ibuprofen, and naproxen
    • History of ulcers or stomach or esophageal conditions
    • Difficulty swallowing
    • Problems sitting or standing for at least 30 minutes
  • Pain in the bones and muscles
  • Problems in the jaw bone
    • Oral or dental surgery
    • Cancer
    • Poor oral hygiene
    • Prolonged use of Fosamax (alendronate)
  • Leg bone fractures
  • Low calcium in the blood
See more detailed risks and warnings
  • Increased risk of blood clots and stroke
    • History of blood clots or stroke
    • History of heart disease
    • Long-distance travel
    • Major surgery
    • Prolonged immobilization
    • Smoking
    • Heart failure
    • High blood pressure
  • Premenopausal women
  • Breast cancer
    • History of breast cancer
  • Overdose
    • History of liver disease
    • History of kidney disease
    • Taking estrogen
See more detailed risks and warnings