Compare Gablofen vs. Norflex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Gablofen (baclofen)

Prescription only

Norflex (orphenadrine)

Prescription only
Works well to control muscle spasticity.

Gablofen (baclofen) is effective for long term spastic conditions, such as multiple sclerosis, spinal cord injury, and others. It is administered intrathecally by a pump connecting to your spine.

Relaxes your muscles.

Norflex (orphenadrine) can be used for relaxing muscle spasms and it also can relieve pain.

Upsides
  • Gablofen (baclofen) is the agent of choice for treatment of muscle spasticity.
  • Gablofen (baclofen) has fewer side effects than the oral form, since higher levels can be delivered to the spine at lower doses.
  • More effective than placebo for treatment of muscle spasms and nonspecific musculoskeletal pain in the short term.
  • Extended release pills last 12 hours.
  • Available as generic.
Downsides
  • Gablofen (baclofen) can cause sleepiness and drowsiness.
  • Stopping Gablofen (baclofen) right away can be life-threatening, so a doctor would need to help you stop it.
  • Gablofen (baclofen) has to be started in the doctor's office. You or your caregiver need to be trained on how to use the pump.
  • Not a first choice treatment for muscle spasms.
  • Norflex (orphenadrine) can make you sleepy or drowsy.
  • At higher doses, Norflex (orphenadrine) can make you confused or hallucinate.
  • Dry mouth and difficulty urinating can happen at higher doses.
  • Pills cannot be crushed and must be swallowed whole.
  • Can't be used in people with glaucoma, certain types of bowel obstruction or peptic ulcers, prostatic hypertrophy, certain urinary problems, cardio-spasm (megaesophagus) and myasthenia gravis.
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Used for
Dosage forms
  • Injection
  • Extended release pill
  • Pill
  • Injection
Price
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Reviews
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Side effects
21possible side effects
  • Loss of muscle tone
    35%
  • Drowsiness
    19%
  • Headache
    11%
  • Convulsion
    10%
  • Urinary Retention
    8%
  • Dizziness
    8%
  • Nausea
    7%
  • Increased muscle tone
    6%
  • Vomiting
    4%
  • Slowed breathing
    4%
  • Pain
    4%
  • Itchiness
    4%
  • Increased salivation
    3%
  • Swelling of limbs
    3%
  • Back pain
    2%
  • Constipaiton
    2%
  • Diarrhea
    2%
  • Weak muscles
    2%
  • Pneumonia
    2%
  • Urination control problems
    2%
  • Inability to urinate
    2%
See more detailed side effects
The Norflex (orphenadrine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Withdrawal symptoms
    • Stopping Gablofen (baclofen) too quickly
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
  • Seizures
    • Higher dose
    • Using other medicines that can cause seizures
    • History of seizures
    • Alcoholism
    • Eating disorders
    • Brain infections
See more detailed risks and warnings
  • Sleepiness and dizziness
    • Taking other medications that also cause sleepiness
    • Recreational drug use
    • Excessive alcohol use
  • Abuse, dependence and withdrawal
    • Prior history of drug abuse
  • Heart problems
    • History of fast or irregular heartbeat
    • History of heart failure or other heart problems
See more detailed risks and warnings