Compare Geodon vs. Saphris

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Geodon (ziprasidone)

Prescription only

Saphris (asenapine)

Prescription only
Helps control your thoughts and mood.

Geodon (ziprasidone) treats bipolar disorder and schizophrenia with fewer side effects than similar medications, but has a risk of abnormal heart rhythm.

3.4/ 5 average rating with 23 reviewsforGeodon
Treats bipolar disorder and schizophrenia.

While Saphris (asenapine) has fewer side effects compared with other medicines that treat bipolar disorder and schizophrenia, it can be more expensive.

Upsides
  • Geodon (ziprasidone) effectively stabilizes mood in schizophrenia and bipolar disorder.
  • Compared to other antipsychotics, this drug has a lower risk of weight gain, high blood sugars, and high cholesterol.
  • Geodon (ziprasidone) capsule is available as a generic.
  • Available as a daily pill for long-term treatment.
  • Saphris (asenapine) can be used to treat bipolar disorder in children age 10 or older, and schizophrenia in children age 12 or older.
  • You don't need water to take Saphris (asenapine); the pill dissolves in your mouth right away.
  • Compared to other medicines, the side effects of Saphris (asenapine) are milder.
Downsides
  • It may take several weeks before you feel the full effects of Geodon (ziprasidone).
  • Might not be a good option if you have a history of heart problems.
  • You will need to get blood tests before you start taking Geodon (ziprasidone) to make sure you're healthy enough to take it.
  • People who are also taking diuretics will need regular blood tests while on Geodon (ziprasidone).
  • Saphris (asenapine) is only available as a brand name.
  • Compared to other medicines, Saphris (asenapine) can cause changes in your hormones and make you sleepy.
  • You have to take Saphris (asenapine) twice a day, which can be hard to remember.
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Used for
Dosage forms
  • Pill
  • Dissolving pill
Price
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Reviews
23 reviews so far
43%
saidit'sworth it
43%
saiditworked well
30%
saidit'sa big hassle

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Side effects
23possible side effects
  • Sleepiness
    31%
  • Movement problems
    31%
  • Headache
    18%
  • Dizziness
    16%
  • Nausea
    10%
  • Restlessness
    10%
  • Weakness
    6%
  • Abnormal vision
    6%
  • Diarrhea
    5%
  • Dry mouth
    5%
  • Vomiting
    5%
  • Anxiety
    5%
  • Accidental injury
    4%
  • Increased salivation
    4%
  • High blood pressure
    3%
  • Tongue swelling
    3%
  • Sore throat
    3%
  • Difficulty swallowing
    2%
  • Muscle pain
    2%
  • Loss of sensation
    2%
  • Speech disorder
    2%
  • Shortness of breath
    2%
  • Itchy, red skin
    2%
See more detailed side effects
10possible side effects
  • Sleepiness
    22%
  • Trouble sleeping
    10%
  • Difficulty controlling movements
    6%
  • Numbness in the mouth
    5%
  • Fatigue
    4%
  • Dizziness
    4%
  • Indigestion
    3%
  • Swelling in the arms and legs
    3%
  • Weight gain
    3%
  • High blood pressure
    3%
See more detailed side effects
Risks and risk factors
  • Increased risk of death
    • Elderly patients with dementia
  • Suicidal thoughts or behavior
  • Heart problems
    • History of heart problems
    • Taking other drugs that also cause heart rhythm changes
    • Low potassium
    • Low magnesium
  • Neuroleptic malignant syndrome (NMS)
  • Abnormal and involuntary muscle movements
    • Taking Geodon (ziprasidone) in higher doses or for a long time
    • Elderly women
  • Dizziness and falls
    • Dehydration
    • Taking blood pressure medications
    • History of heart disease
See more detailed risks and warnings
  • Higher risk of death
    • People age 65 or older with dementia and psychosis
  • Neuroleptic malignant syndrome
    • Taking antipsychotic medications
  • Difficulty controlling movements
  • Weight gain and diabetes
  • Changes in blood pressure and fainting
    • High blood pressure
    • History of heart disease
  • Higher risk of infection
See more detailed risks and warnings