Compare Glucotrol vs. Invokana
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Lowers blood sugar.
Glucotrol (glipizide) is an effective medicine for lowering blood sugar, but it can cause your blood sugar level to be too low so you must always carry some form of sugar with you that can be readily used.
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3.2/ 5 average rating with 332 reviewsforGlucotrol
Lowers blood sugar.
Invokana (canagliflozin) can be used together with other diabetes medicines to help lower your blood sugar, but it can be expensive because it's brand name.
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4.0/ 5 average rating with 27 reviewsforInvokana
Upsides
- Lowers A1c levels by 1-2%.
- Glucotrol (glipizide) is an oral medicine so it might be a good alternative for those who don't like injections.
- Protects your organs and blood vessels by preventing the harmful effects of high blood sugar levels.
- Okay to use by people with kidney problems.
- Available as a generic form and is relatively cheap.
- Lowers A1C (blood sugar) levels by 1%.
- You only have to take Invokana (canagliflozin) once a day before meals.
- Less likely to cause low blood sugar than other diabetes medicines.
- Also available as a combination drug with metformin (Invokamet).
Downsides
- Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
- While taking Glucotrol (glipizide), your blood sugars should be checked 2 to 5 times a week, but less often once you are on a stable dose.
- Can cause mild weight gain of 2-3lb.
- Might lose its effectiveness over time.
- Needs to be taken 30 minutes before a meal for it to be most effective.
- You're more likely to have broken bones, yeast infections and urinary tract infections with Invokana (canagliflozin).
- There's a rare but serious risk of leg and foot amputations with Invokana (canagliflozin). Talk to your doctor if you develop new pain or infections in your feet.
- Not for people with severe kidney problems.
- Can raise your cholesterol.
- Avoid if you are a heavy drinker of alcohol.
Used for
Dosage forms
- Pill
- Extended release pill
- Pill
Price
Lowest price
$9.99
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$469.88
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Reviews
332 reviews so far
50%
saidit'sworth it
32%
saiditworked well
19%
saidit'sa big hassle
Have you used Glucotrol (glipizide)?
Leave a review27 reviews so far
67%
saidit'sworth it
56%
saiditworked well
19%
saidit'sa big hassle
Have you used Invokana (canagliflozin)?
Leave a reviewSide effects
9possible side effects
- Dizziness7%
- Diarrhea5%
- Nervousness4%
- Tremor4%
- Low blood sugar3%
- Constipation3%
- Passing gas3%
- Nausea3%
- Headache2%
9possible side effects
- Yeast infection in women11%
- Urinary tract infections6%
- Increased urination5%
- Yeast infection in men4%
- Thirst3%
- Vaginal itching2%
- Constipation2%
- Nausea2%
- Abdominal pain2%
Risks and risk factors
- Serious heart problems
- Low blood sugar
- Skipping meals or having inconsistent meal times
- Drinking alcohol
- Using other blood sugar-lowering medicine
- People age 60 or older
- Those with kidney and/or liver problems
- Severe allergic reaction
- History of allergy to sulfa-containing medicine
- Kidney and liver disease
- Those with kidney and/or liver disease
- Breakdown of red blood cells
- People with G6PD deficiency
- Increased risk of leg and foot amputations
- History of amputations
- Peripheral vascular disease (narrowed blood vessels)
- Nerve problems
- Diabetic foot ulcers
- Kidney damage and low blood pressure
- History of kidney damage
- Heart failure
- Blood pressure medicines (water pills, ACE inhibitors, ACE inhibitors)
- Anti-inflammatories (NSAIDs)
- Low blood sugar (hypoglycemia)
- Taking medicines for diabetes
- Genital yeast infection and urinary tract infection
- Increased acid and ketones in the blood
- Long periods of fasting
- Alcohol abuse
- Dehydration
- History of pancreatitis