Compare glyburide vs. Novolog

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Diabeta (glyburide)

Prescription only

Novolog (insulin aspart)

Prescription only
Lowers blood sugar.

Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.

3.3/ 5 average rating with 110 reviewsforglyburide
Lowers blood sugar.

Novolog (insulin aspart) is a fast-acting insulin that provides meal-time blood sugar control. For long-term control, you'll need to take Novolog (insulin aspart) with other medicines to keep your overall blood sugar down.

3.5/ 5 average rating with 177 reviewsforNovolog
Upsides
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
  • When used correctly, this medication will l lower blood sugar every time you use it and prevent the harmful, long-term effects of high sugar levels on your organs and blood vessels.
  • You can easily change the dose of Novolog (insulin aspart) to fit your individual needs.
  • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
  • Can use Novolog (insulin aspart) even if you have liver or kidney problems, unlike many other blood sugar-lowering medicines.
Downsides
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
  • Have to take insulin by injection.
  • Might have to check your blood sugar multiple times a day, usually before each meal.
  • Novolog (insulin aspart) is likely to cause moderate weight gain.
  • Higher risk of low blood sugar episodes compared to other kinds of diabetes medications.
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Used for
Dosage forms
  • Pill
  • Injection
Price
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Reviews
110 reviews so far
45%
saidit'sworth it
34%
saiditworked well
21%
saidit'sa big hassle

Have you used Diabeta (glyburide)?

Leave a review
177 reviews so far
58%
saidit'sworth it
46%
saiditworked well
19%
saidit'sa big hassle

Have you used Novolog (insulin aspart)?

Leave a review
Side effects
2possible side effects
  • Nausea and heartburn
    2%
  • Skin allergies
    2%
See more detailed side effects
The Novolog (insulin aspart) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Low blood sugar
    • Over age 65
    • Kidney problems
    • Use of other blood sugar lowering medicines
    • Alcohol
    • Intense physical activity
  • Severe allergic reactions
    • History of sulfa allergies
See more detailed risks and warnings
  • Life-threatening low blood sugar (Hypoglycemia)
    • Insulin dose too high
    • Use of other blood sugar lowering medicines
    • Poor injection techniques
    • Changes in meal pattern or exercise
    • Kidney problems
    • Liver problems
  • Complications due to low potassium
    • Use of medications that lower potassium
    • Current imbalance of electrolytes
  • Severe allergic reactions
    • Allergy to insulin
See more detailed risks and warnings