Compare Glyset vs. glyburide

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Glyset (miglitol)

Prescription only

Diabeta (glyburide)

Prescription only
Lowers blood sugar.

Glyset (miglitol) controls your blood sugar, but the side effects and how you're supposed to take it can make it hard to take every day.

Lowers blood sugar.

Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.

3.3/ 5 average rating with 110 reviewsforglyburide
  • Glyset (miglitol) controls post-meal time blood sugars and does not cause weight gain.
  • Glyset (miglitol) doesn't cause low blood sugar as much as other similar medications.
  • Safe for people 65 years and older.
  • Glyset (miglitol) won't increase your risk of bone fractures like some other antidiabetic drugs.
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
  • Glyset (miglitol) isn't a first choice medication because it doesn't lower blood sugar as well as others.
  • You have to take Glyset (miglitol) 3 times a day with each meal.
  • Glyset (miglitol) can cause diarrhea, excessive gas, and stomach pain when you first start taking it.
  • Not recommended for children under 18.
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
Used for
Dosage forms
  • Pill
  • Pill
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Side effects
The Glyset (miglitol) FDA package insert doesn’t have numbers about how common side effects are.
2possible side effects
  • Nausea and heartburn
  • Skin allergies
See more detailed side effects
Risks and risk factors
  • Severely low blood sugar (hypoglycemia)
    • Use of other blood sugar-lowering medications
    • Unstable kidney function
  • Kidney problems
    • History of kidney problems
  • Stomach and intestine problems
    • Inflammatory bowel disease
    • Ulcers
    • Bowel obstruction or blockage
    • Trouble absorbing or digesting food
See more detailed risks and warnings
  • Low blood sugar
    • Over age 65
    • Kidney problems
    • Use of other blood sugar lowering medicines
    • Alcohol
    • Intense physical activity
  • Severe allergic reactions
    • History of sulfa allergies
See more detailed risks and warnings