Compare Glyxambi vs. Glucovance
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Lowers blood sugar.
Glyxambi (empaglifozin / linagliptin) is a combination drug that lowers the number of pills you have to take, but may be more expensive than the individual components.
Lowers blood sugar.
Glyburide / Metformin is an effective combination medicine for lowering blood sugar, but it is likely to cause diarrhea in the first few weeks.
Upsides
- Lowers A1c levels by 1.0-1.5%.
- Can cause weight loss.
- Taken once daily.
- Can lower the risk of death in those with underlying heart disease.
- Glyburide / Metformin effectively lowers blood sugar levels more so than if each of the individual medicines it contains are taken alone.
- Protects your organs and blood vessels from the harmful effects of high blood sugar levels.
- Can potentially lower your "bad cholesterol" levels.
- Glyburide / Metformin is available in a generic form and is cheaper than many other combination diabetes medicines.
Downsides
- May not be good for people who have kidney problems.
- Not available as a generic, so can be more expensive than other diabetes medications.
- Can increase likelihood of urinary tract or yeast infections.
- May cause you to urinate more frequently throughout the day.
- Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
- Glyburide / Metformin is likely to cause nausea, stomach upset, or diarrhea in the first few weeks.
- Not a good treatment option for those with kidney and/or liver problems.
- Drinking large amounts of or frequently using alcohol while taking Glyburide / Metformin can cause harm to your body.
- Can cause some weight gain.
Used for
Dosage forms
- Pill
- Pill
Price
Lowest price
$567.85
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$25.50
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Side effects
4possible side effects
- Urinary tract infection13%
- Upper respiratory tract infection7%
- Common cold6%
- Low blood sugar2%
6possible side effects
- Upper respiratory infection17%
- Diarrhea17%
- Headache9%
- Nausea/vomiting8%
- Stomach pain7%
- Dizziness6%
Risks and risk factors
- Danger from acid (ketones) build up
- Kidney problems
- Liver problems
- Alcohol use
- Age 65 or older
- Surgery
- Contrast Dye
- Congestive heart failure
- Calorie restriction
- Low blood pressure
- Taking blood pressure lowering medications
- Low salt diet
- Kidney problems
- Age 65 or older
- Bone fractures
- Low blood pressure
- Weak bones (Osteoporosis)
- Urinary tract or genital area infections
- History of urinary tract infections
- History of fungal genital infections
- Uncircumcised males
- Pancreas swelling (pancreatitis)
- History of pancreatitis
- History of gallstones
- Alcoholism
- Elevated triglycerides
- Kidney damage
- History of kidney damage
- Heart failure
- Blood pressure medicines (diuretics, ACE inhibitors, ARBs)
- NSAIDs use
- Low blood sugar
- Taking other diabetic medications
- Insulin use
- Sulfonylurea use
- Increased exercise
- Drinking alcohol
- Lactic acid build up in blood
- History of kidney problems
- History of liver problems
- Those with congestive heart failure
- Using contrast dye for procedures
- Undergoing surgery
- Drinking large amounts or frequent use of alcohol
- Serious heart problems
- Low blood sugar
- Skipping meals or having inconsistent meal times
- Drinking alcohol
- Using other blood sugar-lowering medicine
- People age 60 or older
- Those with kidney and/or liver problems
- Severe allergic reaction
- History of allergy to sulfa-containing medicine
- Breakdown of red blood cells
- People with G6PD deficiency