Compare Glyxambi vs. Invokamet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Lowers blood sugar.

Glyxambi (empaglifozin / linagliptin) is a combination drug that lowers the number of pills you have to take, but may be more expensive than the individual components.

Lowers blood sugar.

Invokamet (canagliflozin / metformin) is a combination of 2 medicines that can lower your blood sugars, but it still has to be taken twice daily.

Upsides
  • Lowers A1c levels by 1.0-1.5%.
  • Can cause weight loss.
  • Taken once daily.
  • Can lower the risk of death in those with underlying heart disease.
  • Combines 2 effective anti-diabetes medicines into one pill so you don't have to take them separately.
  • Does not cause weight gain unlike other anti-diabetic medicines.
  • Not as likely to cause hypoglycemia (low blood sugar)
Downsides
  • May not be good for people who have kidney problems.
  • Not available as a generic, so can be more expensive than other diabetes medications.
  • Can increase likelihood of urinary tract or yeast infections.
  • May cause you to urinate more frequently throughout the day.
  • Not a good option if you have worsening kidney function such as those age 65 years and up.
  • May cause increased urination.
  • More likely to cause broken bones and yeast and urinary tract infections.
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Used for
Dosage forms
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Price
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Reviews
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Side effects
4possible side effects
  • Urinary tract infection
    13%
  • Upper respiratory tract infection
    7%
  • Common cold
    6%
  • Low blood sugar
    2%
See more detailed side effects
9possible side effects
  • Yeast infection in women
    11%
  • Urinary tract infections
    6%
  • Increased urination
    5%
  • Yeast infection in men
    4%
  • Thirst
    3%
  • Vaginal itching
    2%
  • Constipation
    2%
  • Nausea
    2%
  • Abdominal pain
    2%
See more detailed side effects
Risks and risk factors
  • Danger from acid (ketones) build up
    • Kidney problems
    • Liver problems
    • Alcohol use
    • Age 65 or older
    • Surgery
    • Contrast Dye
    • Congestive heart failure
    • Calorie restriction
  • Low blood pressure
    • Taking blood pressure lowering medications
    • Low salt diet
    • Kidney problems
    • Age 65 or older
  • Bone fractures
    • Low blood pressure
    • Weak bones (Osteoporosis)
  • Urinary tract or genital area infections
    • History of urinary tract infections
    • History of fungal genital infections
    • Uncircumcised males
  • Pancreas swelling (pancreatitis)
    • History of pancreatitis
    • History of gallstones
    • Alcoholism
    • Elevated triglycerides
  • Kidney damage
    • History of kidney damage
    • Heart failure
    • Blood pressure medicines (diuretics, ACE inhibitors, ARBs)
    • NSAIDs use
  • Low blood sugar
    • Taking other diabetic medications
    • Insulin use
    • Sulfonylurea use
    • Increased exercise
    • Drinking alcohol
See more detailed risks and warnings
  • Acid buildup in the blood
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Contrast dye for procedure
    • Surgery
    • Alcohol use
  • Low blood pressure (hypotension)
    • Over age 65
    • Kidney problems
    • Diuretics
    • Taking ACE inhibitors or ARBs
    • Low blood pressure
  • Bone fractures
    • Low blood pressure
    • Weak bones (Osteoporosis)
  • Kidney damage
    • History of kidney damage
    • Heart failure
    • Blood pressure medicines (water pills, ACE inhibitors, ACE inhibitors)
    • Anti-inflammatories (NSAIDs)
  • Genital yeast infection and urinary tract infection
    • History of urinary tract infections
    • History of fungal genital infections
    • Uncircumcised males
  • Low blood sugars
    • Taking other diabetic medications
    • Increased exercise
    • Drinking alcohol
See more detailed risks and warnings