Compare Glyxambi vs. Invokamet
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Lowers blood sugar.
Glyxambi (empaglifozin / linagliptin) is a combination drug that lowers the number of pills you have to take, but may be more expensive than the individual components.
Lowers blood sugar.
Invokamet (canagliflozin / metformin) is a combination of 2 medicines that can lower your blood sugars, but it still has to be taken twice daily.
Upsides
- Lowers A1c levels by 1.0-1.5%.
- Can cause weight loss.
- Taken once daily.
- Can lower the risk of death in those with underlying heart disease.
- Combines 2 effective anti-diabetes medicines into one pill so you don't have to take them separately.
- Does not cause weight gain unlike other anti-diabetic medicines.
- Not as likely to cause hypoglycemia (low blood sugar)
Downsides
- May not be good for people who have kidney problems.
- Not available as a generic, so can be more expensive than other diabetes medications.
- Can increase likelihood of urinary tract or yeast infections.
- May cause you to urinate more frequently throughout the day.
- Not a good option if you have worsening kidney function such as those age 65 years and up.
- May cause increased urination.
- More likely to cause broken bones and yeast and urinary tract infections.
Used for
Dosage forms
- Pill
- Pill
Price
Lowest price
$548.17
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$518.64
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Reviews
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Side effects
4possible side effects
- Urinary tract infection13%
- Upper respiratory tract infection7%
- Common cold6%
- Low blood sugar2%
9possible side effects
- Yeast infection in women11%
- Urinary tract infections6%
- Increased urination5%
- Yeast infection in men4%
- Thirst3%
- Vaginal itching2%
- Constipation2%
- Nausea2%
- Abdominal pain2%
Risks and risk factors
- Danger from acid (ketones) build up
- Kidney problems
- Liver problems
- Alcohol use
- Age 65 or older
- Surgery
- Contrast Dye
- Congestive heart failure
- Calorie restriction
- Low blood pressure
- Taking blood pressure lowering medications
- Low salt diet
- Kidney problems
- Age 65 or older
- Bone fractures
- Low blood pressure
- Weak bones (Osteoporosis)
- Urinary tract or genital area infections
- History of urinary tract infections
- History of fungal genital infections
- Uncircumcised males
- Pancreas swelling (pancreatitis)
- History of pancreatitis
- History of gallstones
- Alcoholism
- Elevated triglycerides
- Kidney damage
- History of kidney damage
- Heart failure
- Blood pressure medicines (diuretics, ACE inhibitors, ARBs)
- NSAIDs use
- Low blood sugar
- Taking other diabetic medications
- Insulin use
- Sulfonylurea use
- Increased exercise
- Drinking alcohol
- Acid buildup in the blood
- Kidney problems
- Liver problems
- Congestive heart failure
- Contrast dye for procedure
- Surgery
- Alcohol use
- Low blood pressure (hypotension)
- Over age 65
- Kidney problems
- Diuretics
- Taking ACE inhibitors or ARBs
- Low blood pressure
- Bone fractures
- Low blood pressure
- Weak bones (Osteoporosis)
- Kidney damage
- History of kidney damage
- Heart failure
- Blood pressure medicines (water pills, ACE inhibitors, ACE inhibitors)
- Anti-inflammatories (NSAIDs)
- Genital yeast infection and urinary tract infection
- History of urinary tract infections
- History of fungal genital infections
- Uncircumcised males
- Low blood sugars
- Taking other diabetic medications
- Increased exercise
- Drinking alcohol