Compare Glyxambi vs. Jardiance

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Lowers blood sugar.

Glyxambi (empaglifozin / linagliptin) is a combination drug that lowers the number of pills you have to take, but may be more expensive than the individual components.

Lowers blood sugar.

Jardiance (empagliflozin) lowers blood sugar for people with diabetes, but can increase the chance of a yeast infection.

Upsides
  • Lowers A1c levels by 1.0-1.5%.
  • Can cause weight loss.
  • Taken once daily.
  • Can lower the risk of death in those with underlying heart disease.
  • Lowers A1c (average blood sugar over time) levels up to 1%.
  • Can prevent death from heart attack, stroke, or heart failure if you have pre-existing heart disease.
  • Can be easily taken orally as a pill.
  • Can cause weight loss.
  • Not likely to cause hypoglycemia or very low blood sugar.
Downsides
  • May not be good for people who have kidney problems.
  • Not available as a generic, so can be more expensive than other diabetes medications.
  • Can increase likelihood of urinary tract or yeast infections.
  • May cause you to urinate more frequently throughout the day.
  • More expensive since it's available as brand name only.
  • Can cause dehydration.
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Used for
Dosage forms
  • Pill
  • Pill
Price
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Reviews
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Side effects
4possible side effects
  • Urinary tract infection
    13%
  • Upper respiratory tract infection
    7%
  • Common cold
    6%
  • Low blood sugar
    2%
See more detailed side effects
9possible side effects
  • Low blood sugar
    40%
  • Urinary tract infection
    9%
  • Yeast infection in women
    5%
  • Elevated cholesterol levels
    4%
  • Head cold
    3%
  • Increased urination
    3%
  • Yeast infection in men
    3%
  • Joint pain
    2%
  • Nausea
    2%
See more detailed side effects
Risks and risk factors
  • Danger from acid (ketones) build up
    • Kidney problems
    • Liver problems
    • Alcohol use
    • Age 65 or older
    • Surgery
    • Contrast Dye
    • Congestive heart failure
    • Calorie restriction
  • Low blood pressure
    • Taking blood pressure lowering medications
    • Low salt diet
    • Kidney problems
    • Age 65 or older
  • Bone fractures
    • Low blood pressure
    • Weak bones (Osteoporosis)
  • Urinary tract or genital area infections
    • History of urinary tract infections
    • History of fungal genital infections
    • Uncircumcised males
  • Pancreas swelling (pancreatitis)
    • History of pancreatitis
    • History of gallstones
    • Alcoholism
    • Elevated triglycerides
  • Kidney damage
    • History of kidney damage
    • Heart failure
    • Blood pressure medicines (diuretics, ACE inhibitors, ARBs)
    • NSAIDs use
  • Low blood sugar
    • Taking other diabetic medications
    • Insulin use
    • Sulfonylurea use
    • Increased exercise
    • Drinking alcohol
See more detailed risks and warnings
  • Low blood pressure
    • Over age 65
    • Kidney disease
    • Taking blood pressure medications
  • Worsening kidney function
    • Dehydration
    • Poor baseline kidney function
    • Congestive heart failure
  • Too much acid in the blood
    • Type 1 diabetes
    • Extended fasting
  • Yeast infections and urinary tract infections
See more detailed risks and warnings