Compare Glyxambi vs. Metaglip

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lowers blood sugar.

Glyxambi (empaglifozin / linagliptin) is a combination drug that lowers the number of pills you have to take, but may be more expensive than the individual components.

No information currently available
  • Lowers A1c levels by 1.0-1.5%.
  • Can cause weight loss.
  • Taken once daily.
  • Can lower the risk of death in those with underlying heart disease.
No information currently available
  • May not be good for people who have kidney problems.
  • Not available as a generic, so can be more expensive than other diabetes medications.
  • Can increase likelihood of urinary tract or yeast infections.
  • May cause you to urinate more frequently throughout the day.
No information currently available
Used for
  • Diabetes mellitus type 2
Dosage forms
  • Pill
  • Pill
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Side effects
4possible side effects
  • Urinary tract infection
  • Upper respiratory tract infection
  • Common cold
  • Low blood sugar
See more detailed side effects
The Metaglip (Metformin / Glipizide) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Danger from acid (ketones) build up
    • Kidney problems
    • Liver problems
    • Alcohol use
    • Age 65 or older
    • Surgery
    • Contrast Dye
    • Congestive heart failure
    • Calorie restriction
  • Low blood pressure
    • Taking blood pressure lowering medications
    • Low salt diet
    • Kidney problems
    • Age 65 or older
  • Bone fractures
    • Low blood pressure
    • Weak bones (Osteoporosis)
  • Urinary tract or genital area infections
    • History of urinary tract infections
    • History of fungal genital infections
    • Uncircumcised males
  • Pancreas swelling (pancreatitis)
    • History of pancreatitis
    • History of gallstones
    • Alcoholism
    • Elevated triglycerides
  • Kidney damage
    • History of kidney damage
    • Heart failure
    • Blood pressure medicines (diuretics, ACE inhibitors, ARBs)
    • NSAIDs use
  • Low blood sugar
    • Taking other diabetic medications
    • Insulin use
    • Sulfonylurea use
    • Increased exercise
    • Drinking alcohol
See more detailed risks and warnings
No information currently available