Compare Glyxambi vs. Onglyza

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Lowers blood sugar.

Glyxambi (empaglifozin / linagliptin) is a combination drug that lowers the number of pills you have to take, but may be more expensive than the individual components.

Lowers blood sugar.

Onglyza (saxagliptin) can cause heart failure unlike other medicines that work just like it.

Upsides
  • Lowers A1c levels by 1.0-1.5%.
  • Can cause weight loss.
  • Taken once daily.
  • Can lower the risk of death in those with underlying heart disease.
  • DRUG-NAME is an oral blood sugar lowering medicine. It's a good option if you don't like injections.
  • Does not cause weight gain.
  • May be a good option for those with bad liver function.
  • Does not cause hypoglycemia (low blood sugar) when taken by itself.
Downsides
  • May not be good for people who have kidney problems.
  • Not available as a generic, so can be more expensive than other diabetes medications.
  • Can increase likelihood of urinary tract or yeast infections.
  • May cause you to urinate more frequently throughout the day.
  • Typically not first-choice treatment for diabetes.
  • Only lowers A1C (average blood sugar over time) by ~0.5%.
  • Risk for heart failure has not been seen in other medicines that work just like it.
  • May be more expensive than other anti-diabetic medicines.
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Dosage forms
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Price
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Reviews
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Side effects
4possible side effects
  • Urinary tract infection
    13%
  • Upper respiratory tract infection
    7%
  • Common cold
    6%
  • Low blood sugar
    2%
See more detailed side effects
The Onglyza (saxagliptin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Danger from acid (ketones) build up
    • Kidney problems
    • Liver problems
    • Alcohol use
    • Age 65 or older
    • Surgery
    • Contrast Dye
    • Congestive heart failure
    • Calorie restriction
  • Low blood pressure
    • Taking blood pressure lowering medications
    • Low salt diet
    • Kidney problems
    • Age 65 or older
  • Bone fractures
    • Low blood pressure
    • Weak bones (Osteoporosis)
  • Urinary tract or genital area infections
    • History of urinary tract infections
    • History of fungal genital infections
    • Uncircumcised males
  • Pancreas swelling (pancreatitis)
    • History of pancreatitis
    • History of gallstones
    • Alcoholism
    • Elevated triglycerides
  • Kidney damage
    • History of kidney damage
    • Heart failure
    • Blood pressure medicines (diuretics, ACE inhibitors, ARBs)
    • NSAIDs use
  • Low blood sugar
    • Taking other diabetic medications
    • Insulin use
    • Sulfonylurea use
    • Increased exercise
    • Drinking alcohol
See more detailed risks and warnings
  • inflammation of the pancreas
    • Alcoholism
    • Elevated triglycerides
    • History of pancreatitis
    • Gallstones
  • Heart failure
    • History of heart failure
    • Bad kidney function
  • Low blood sugar (hypoglycemia)
    • Alcohol
    • Unexpected changes in diet
    • Changes in amount of exercise
    • Taking other anti-diabetic medications
  • Severe allergic reactions
  • Severe joint pain
  • Fluid-filled blisters on the skin (bullous pemphigoid)
See more detailed risks and warnings