Compare granisetron vs. Emend

Head-to-head comparisons of medication uses, side effects, ratings, and more.

ADVERTISEMENT

granisetron

Prescription only

Emend (aprepitant)

Prescription only
Helps prevent nausea and vomiting due to chemotherapy or radiation treatment

granisetron is a safe and effective medication used for preventing nausea and vomiting due to chemotherapy and radiation, but it can be very expensive.

Stops nausea and vomitting caused by chemotherapy and surgery.

Emend (aprepitant) is used with other medicines to stop nausea and vomiting that can happen after chemotherapy and surgery.

Upsides
  • granisetron is effective even for those who are using chemotherapy that is associated with a high risk for causing nausea and vomiting.
  • Safe and effective option for older people, unlike some other alternatives.
  • You only need to take granisetron on the days you actually receive chemotherapy and radiation.
  • A patch form of the medication is available for those who don't want to or who are unable to take pills.
  • Safe to use for people with kidney problems.
  • Emend (aprepitant) can help stop nausea that lasts several days after receiving chemo, which is harder to control than the nausea that starts immediately.
  • Emend (aprepitant) can also be used to stop nausea in adults that happens after surgery.
  • Emend (aprepitant) also comes as a liquid for children over 6 months and adults who can't take pills.
  • The side effects of Emend (aprepitant) are usually mild and include hiccups and fatigue.
Downsides
  • granisetron only prevents symptoms of nausea and vomiting so you must take the medication before you get chemotherapy or radiation treatment.
  • Can affect the natural rhythm of your heart, especially if you take other medications that can also potentially cause the same problem.
  • Might not be a good option for those who are on certain antidepressants.
  • granisetron is very expensive compared to similar alternatives.
  • Very likely to cause side effects like headache and constipation.
  • Emend (aprepitant) only stops nausea and vomiting from happening. It won't work if you already have nausea and vomiting.
  • Emend (aprepitant) has to be used in combination with other medicines to treat chemotherapy related nausea.
  • Emend (aprepitant) needs to be taken for the first three days of chemo.
ADVERTISEMENT
Used for
  • Prevention of chemotherapy-associated nausea and vomiting
  • Prevention of radiation-associated nausea and vomiting
  • Prevention of post-surgery nausea and vomiting
  • Prevention of acute and delayed nausea and vomiting associated with highly-emetogenic chemotherapy
  • Prevention of acute and delayed nausea and vomiting associated with moderately-emetogenic chemotherapy
  • Prevention of postoperative nausea and vomiting
Dosage forms
  • Pill
  • Pill
  • Liquid
Price
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Reviews
Not enough review data.Leave a review
Not enough review data.Leave a review
Side effects
6possible side effects
  • Headache
    20%
  • Weakness
    18%
  • Constipation
    14%
  • Diarrhea
    9%
  • Indigestion
    6%
  • Stomach pain
    4%
See more detailed side effects
6possible side effects
  • Fatigue
    13%
  • Diarrhea
    9%
  • Weakness
    7%
  • Indigestion
    7%
  • Hiccups
    5%
  • Lower white blood cells
    4%
See more detailed side effects
Risks and risk factors
  • Serotonin syndrome
    • Taking other medications that also affect serotonin levels in the brain
  • Effects on heart
    • History of arrhythmias
    • Taking other medications that can also cause irregular heartbeat
    • Electrolyte imbalance
  • Constipation
    • History of constipation problems
    • Those who had recent abdominal surgery
See more detailed risks and warnings
  • Drug Interactions
  • Decreased INR when used with warfarin (Coumadin)
    • Taking warfarin with Emend (aprepitant)
  • Risk of reduced efficacy of hormone based birth control
    • Taking hormone-based birth control
See more detailed risks and warnings