Compare granisetron vs. Sustol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Helps prevent nausea and vomiting due to chemotherapy or radiation treatment

granisetron is a safe and effective medication used for preventing nausea and vomiting due to chemotherapy and radiation, but it can be very expensive.

Helps prevent nausea and vomiting due to cancer chemotherapies.

Sustol (granisetron) is a long-acting injection that helps to prevent nausea and vomiting due to cancer chemotherapies, but causes bleeding and bruising at the injection site.

Upsides
  • granisetron is effective even for those who are using chemotherapy that is associated with a high risk for causing nausea and vomiting.
  • Safe and effective option for older people, unlike some other alternatives.
  • You only need to take granisetron on the days you actually receive chemotherapy and radiation.
  • A patch form of the medication is available for those who don't want to or who are unable to take pills.
  • Safe to use for people with kidney problems.
  • Each dose of Sustol (granisetron) provides relief from nausea and vomiting for at least 7 days.
  • Dosing is less frequent than alternatives.
  • Injection may be preferrable if you have difficulty swallowing a pill.
Downsides
  • granisetron only prevents symptoms of nausea and vomiting so you must take the medication before you get chemotherapy or radiation treatment.
  • Can affect the natural rhythm of your heart, especially if you take other medications that can also potentially cause the same problem.
  • Might not be a good option for those who are on certain antidepressants.
  • granisetron is very expensive compared to similar alternatives.
  • Very likely to cause side effects like headache and constipation.
  • Sustol (granisetron) must be given at the doctor's office or infusion center 30 minutes before chemotherapy.
  • The dose of Sustol (granisetron) needs to be adjusted if you have poor kidney function.
  • Available as an expensive, branded product only.
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Used for
  • Prevention of chemotherapy-associated nausea and vomiting
  • Prevention of radiation-associated nausea and vomiting
  • Prevention of post-surgery nausea and vomiting
  • Prevention of nausea and vomiting due to cancer chemotherapy
Dosage forms
  • Pill
  • Extended-release injection
Price
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Reviews
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Side effects
6possible side effects
  • Headache
    20%
  • Weakness
    18%
  • Constipation
    14%
  • Diarrhea
    9%
  • Indigestion
    6%
  • Stomach pain
    4%
See more detailed side effects
The Sustol (granisetron) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Serotonin syndrome
    • Taking other medications that also affect serotonin levels in the brain
  • Effects on heart
    • History of arrhythmias
    • Taking other medications that can also cause irregular heartbeat
    • Electrolyte imbalance
  • Constipation
    • History of constipation problems
    • Those who had recent abdominal surgery
See more detailed risks and warnings
  • Serotonin syndrome
    • Taking other medicines that affect serotonin levels such as anti-depressants
  • Troublesome stomach side-effects (ileus)
    • Taking other medications that cause constipation such as Norco and Percocet.
  • Injection site reactions
    • Bruising/bleeding more likely if also taking medications that affect blood coagulation
  • Allergic reactions
See more detailed risks and warnings