Compare Haldol vs. Clozaril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Haldol (haloperidol)

Prescription only

Clozaril (clozapine)

Prescription only
Helps control your thoughts, calm agitation, and stabilize your mood.

Haldol (haloperidol) is less likely to cause weight gain and sedation, but more likely to cause movement disorders compared to other antipsychotics.

3.1/ 5 average rating with 50 reviewsforHaldol
Helps control your thoughts and actions.

Clozaril (clozapine) treats schizophrenia when other drugs haven't worked, but you'll have to get regular blood work done because it can have very serious side effects.

Upsides
  • Haldol (haloperidol) is available in a cheap, generic version.
  • A monthly extended-release injection allows for more convenient dosing than a daily pill.
  • Studies show that Clozaril (clozapine) effectively treats schizophrenia when other medications have failed. Clozaril (clozapine) also reduces risk of suicidal behavior.
  • Has the lowest risk of causing movement problems when compared to other antipsychotic medicines.
  • Clozaril (clozapine) is available as a normal tablet and as a mint-flavored tablet that dissolves on the tongue without water.
  • Safer than other similar medicines during pregnancy.
  • Available as a generic, which is cheaper.
Downsides
  • Haldol (haloperidol) is an older medicine and has a lot more problematic side effects compared to newer antipsychotics.
  • You might need routine blood tests and regular check-ups to make sure the medicine is working for you.
  • You need to get blood work done every time you get a prescription filled for Clozaril (clozapine). Once it is ready at the pharmacy, you need to pick it up within 7 days.
  • You can only get Clozaril (clozapine) at certain pharmacies that are registered to provide it.
  • You need to limit the amount of alcohol you drink while taking Clozaril (clozapine).
  • Clozaril (clozapine) can cause high blood sugar, high cholesterol, and weight gain.
  • May not be optimal for someone with a history of seizures.
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Used for
  • Schizophrenia
  • Suicidal behavior in schizophrenia
  • Psychosis in Parkinson's disease
Dosage forms
  • Pill
  • Liquid
  • Injection
  • Pill
  • Dissolving tablet
  • Liquid
Price
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Reviews
50 reviews so far
38%
saidit'sworth it
42%
saiditworked well
34%
saidit'sa big hassle

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Side effects
The Haldol (haloperidol) FDA package insert doesn’t have numbers about how common side effects are.
31possible side effects
  • Drowsiness/sedation
    39%
  • Salivation
    31%
  • Fast heartbeat
    25%
  • Dizziness/vertigo
    19%
  • Constipation
    14%
  • Low blood pressure
    9%
  • Headache
    7%
  • Tremor
    6%
  • Fainting
    6%
  • Sweating
    6%
  • Dry mouth
    6%
  • Nausea
    5%
  • Vision problems
    5%
  • Fever
    5%
  • Disturbed sleep/nightmares
    4%
  • Restlessness
    4%
  • Loss of muscle movement
    4%
  • Agitation
    4%
  • High blood pressure
    4%
  • Stomach discomfort/heartburn
    4%
  • Weight gain
    4%
  • Seizures (convulsions)
    3%
  • Rigidity
    3%
  • Confusion
    3%
  • Nausea/vomiting
    3%
  • Low white blood cells
    3%
  • Fatigue
    2%
  • Trouble sleeping
    2%
  • Diarrhea
    2%
  • Problems urinating
    2%
  • Rash
    2%
See more detailed side effects
Risks and risk factors
  • Increased risk of death
    • Elderly patients with dementia
  • Blood disorders
  • Neuroleptic malignant syndrome
  • Heart problems
    • History of heart problems
    • Drug interactions
  • Shaking and restlessness
  • Driving impairment
    • Drinking alcohol
    • Taking other medicines that make you less alert
See more detailed risks and warnings
  • Low white blood cells
  • Low blood pressure, slow heartbeat, and fainting
    • Dehydration
    • Taking blood pressure medications
    • Heart failure
  • Seizures
    • Seizure disorder
    • Alcohol abuse
  • Heart problems
    • History of heart problems
  • Increased risk of death in elderly with dementia
    • Over 65 with dementia
  • High blood sugar, high cholesterol, and weight gain
See more detailed risks and warnings