Compare Harvoni vs. Copegus

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats hepatitis C.

Harvoni (ledipasvir / sofosbuvir) is a combination pill for hepatitis C that you only need to take once a day. Depending on the amount of liver damage you have, it's sometimes taken together with another medicine called ribavirin.

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  • Harvoni (ledipasvir / sofosbuvir) is a simple hepatitis C treatment that can cure 96% to 99% of those with genotype 1 who have had no prior treatment. Most people only have to take 1 pill a day for either 12 or 24 weeks.
  • The most common side effects are mild to moderate tiredness and headache.
  • Harvoni (ledipasvir / sofosbuvir) is also a good option for people taking HIV medications since it doesn't have drug interactions with most of these medicines.
  • Harvoni (ledipasvir / sofosbuvir) is approved for the treatment of hepatitis C in some people with severe liver disease and liver transplants.
  • Harvoni (ledipasvir / sofosbuvir) is also one of the first drugs approved to treat hepatitis C in children ages 12 to 17.
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  • Harvoni (ledipasvir / sofosbuvir) needs an acidic stomach to be absorbed properly. This means that heartburn medications can affect how Harvoni (ledipasvir / sofosbuvir) works, so talk to you doctor or pharmacist before starting any.
  • Harvoni (ledipasvir / sofosbuvir) can cause serious drops in heart rate when it’s taken with amiodarone. If you have to take them together, your heart rate needs to be checked regularly.
  • You should be tested for hepatitis B before starting Harvoni (ledipasvir / sofosbuvir), since untreated hepatitis B can become active again with medications that treat hepatitis C.
  • If you have severe liver disease or have a liver transplant, you'll have to take Harvoni (ledipasvir / sofosbuvir) with another medicine called ribavirin.
  • Talk to your doctor if you're currently on rosuvastatin, as you shouldn’t take it with Harvoni (ledipasvir / sofosbuvir).
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Used for
  • Hepatitis C infection genotype 1, 4, 5, and 6
  • Hematopoietic stem cell transplant - Respiratory syncytial virus infection Hepatitis C
  • Chronic
  • Combination therapy in interferon alfa-naive patients with compensated liver disease - HIV infection Hepatitis C
  • Chronic
  • With compensated liver disease Respiratory syncytial virus infection
  • Herpes simplex Influenza Viral hemorrhagic fever
Dosage forms
  • Pill
  • Pill
  • Liquid
  • Inhaler
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Side effects
8possible side effects
  • Weakness / lack of energy
  • Headache
  • Tiredness
  • Muscle pain
  • Irritability
  • Cough
  • Dizziness
  • Shortness of breath
See more detailed side effects
The Copegus (Ribavirin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Hepatitis B reactivation
    • History of hepatitis B infection
  • Slow heart rate
    • Amiodarone
    • Beta blockers
    • Heart disease
    • Liver disease
  • Drug interactions
    • Taking rifampin
    • Taking St. John's wort
  • Ribavirin combination treatment
    • Taking ribavirin with Harvoni (ledipasvir / sofosbuvir)
See more detailed risks and warnings
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