Compare Harvoni vs. Epclusa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats hepatitis C.

Harvoni (ledipasvir / sofosbuvir) is a combination pill for hepatitis C that you only need to take once a day. Depending on the amount of liver damage you have, it's sometimes taken together with another medicine called ribavirin.

Treats hepatitis C.

Epclusa (velpatasvir / sofosbuvir) is a combination medicine that treats hepatitis C, and has been shown very effective at curing the disease in many people. It is very expensive.

Upsides
  • Harvoni (ledipasvir / sofosbuvir) is a simple hepatitis C treatment that can cure 96% to 99% of those with genotype 1 who have had no prior treatment. Most people only have to take 1 pill a day for either 12 or 24 weeks.
  • The most common side effects are mild to moderate tiredness and headache.
  • Harvoni (ledipasvir / sofosbuvir) is also a good option for people taking HIV medications since it doesn't have drug interactions with most of these medicines.
  • Harvoni (ledipasvir / sofosbuvir) is approved for the treatment of hepatitis C in some people with severe liver disease and liver transplants.
  • Harvoni (ledipasvir / sofosbuvir) is also one of the first drugs approved to treat hepatitis C in children ages 12 to 17.
  • Epclusa (velpatasvir / sofosbuvir) is the first medicine approved to treat all genotypes of hepatitis C.
  • Most people only have to take one pill of Epclusa (velpatasvir / sofosbuvir) once a day for 12 weeks. If you have severe liver damage, you'll have to take it with ribavirin.
  • It can be taken with or without food.
  • The most common side effects are usually mild, including fatigue and headache.
Downsides
  • Harvoni (ledipasvir / sofosbuvir) needs an acidic stomach to be absorbed properly. This means that heartburn medications can affect how Harvoni (ledipasvir / sofosbuvir) works, so talk to you doctor or pharmacist before starting any.
  • Harvoni (ledipasvir / sofosbuvir) can cause serious drops in heart rate when it’s taken with amiodarone. If you have to take them together, your heart rate needs to be checked regularly.
  • You should be tested for hepatitis B before starting Harvoni (ledipasvir / sofosbuvir), since untreated hepatitis B can become active again with medications that treat hepatitis C.
  • If you have severe liver disease or have a liver transplant, you'll have to take Harvoni (ledipasvir / sofosbuvir) with another medicine called ribavirin.
  • Talk to your doctor if you're currently on rosuvastatin, as you shouldn’t take it with Harvoni (ledipasvir / sofosbuvir).
  • Epclusa (velpatasvir / sofosbuvir) can only be absorbed properly in an acidic stomach so heartburn meds can affect how well it works.
  • Epclusa (velpatasvir / sofosbuvir) can cause serious drops in heart rate when it is taken with amiodarone.
  • If you have severe liver disease, you'll have to take Epclusa (velpatasvir / sofosbuvir) with another medication called ribavirin.
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Used for
  • Hepatitis C infection genotype 1, 4, 5, and 6
Dosage forms
  • Pill
  • Pill
Price
Lowest price
$23468.18
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Lowest price
$24754.11
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Reviews
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Side effects
8possible side effects
  • Weakness / lack of energy
    31%
  • Headache
    28%
  • Tiredness
    18%
  • Muscle pain
    9%
  • Irritability
    8%
  • Cough
    5%
  • Dizziness
    5%
  • Shortness of breath
    3%
See more detailed side effects
5possible side effects
  • Headache
    22%
  • Fatigue
    15%
  • Nausea
    9%
  • Weakness
    5%
  • Insomnia
    5%
See more detailed side effects
Risks and risk factors
  • Hepatitis B reactivation
    • History of hepatitis B infection
  • Slow heart rate
    • Amiodarone
    • Beta blockers
    • Heart disease
    • Liver disease
  • Drug interactions
    • Taking rifampin
    • Taking St. John's wort
  • Ribavirin combination treatment
    • Taking ribavirin with Harvoni (ledipasvir / sofosbuvir)
See more detailed risks and warnings
  • Hepatitis B reactivation
    • History of hepatitis B infection
  • Slower heart beat
    • Amiodarone
    • Beta blockers
    • Heart disease
    • Liver disease
  • Drug interactions
  • Ribavirin warnings
    • Taking ribavirin with Epclusa (velpatasvir / sofosbuvir)
See more detailed risks and warnings